5-(3,5-Difluoro-benzyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

Base Information

• Chemical Name: 5-(3,5-Difluoro-benzyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one
• CAS No.: 168285-29-8
• Molecular Formula: C₁₁H₈F₂N₂OS
• Molecular Weight: 254.26
• Mol file: 168285-29-8.mol

Synonyms:5-(3,5-Difluoro-benzyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

Chemical Property of 5-(3,5-Difluoro-benzyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(3,5-Difluoro-benzyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

There total 3 articles about 5-(3,5-Difluoro-benzyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-difluorocinnamic acid (84315-23-1) → 5-(3,5-Difluoro-benzyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (168285-29-8)

Guidance literature:

Multi-step reaction with 3 steps

1: HCl / diethyl ether / Heating

2: H₂ / PtO₂ / ethanol

3: 1.) Na, 3.) conc. HCl

With hydrogenchloride; hydrogen; sodium; platinum(IV) oxide; In diethyl ether; ethanol;

DOI:10.1021/jm00019a015

Reference yield:

ethyl 3-(3,5-difluorophenyl)acrylate (163978-50-5) → 5-(3,5-Difluoro-benzyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (168285-29-8)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / PtO₂ / ethanol

2: 1.) Na, 3.) conc. HCl

With hydrogenchloride; hydrogen; sodium; platinum(IV) oxide; In ethanol;

DOI:10.1021/jm00019a015

Reference yield:

thiourea (17356-08-0) + ethyl 3-(3,5-difluorophenyl)propionate (163978-51-6) + formic acid ethyl ester (109-94-4) → 5-(3,5-Difluoro-benzyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (168285-29-8)

Guidance literature:

With hydrogenchloride; sodium; Multistep reaction;

DOI:10.1021/jm00019a015

upstream raw materials:

thiourea

ethyl 3-(3,5-difluorophenyl)propionate

formic acid ethyl ester

3,5-difluorocinnamic acid

Downstream raw materials:

Acetic acid 2-[5-(3,5-difluoro-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy]-ethyl ester

5-(3,5-Difluoro-benzyl)-1H-pyrimidine-2,4-dione