2-((S)-4-Carboxy-1-methyl-butoxycarbonylmethyl)-4,6-dimethoxy-benzoic acid

Base Information

• Chemical Name: 2-((S)-4-Carboxy-1-methyl-butoxycarbonylmethyl)-4,6-dimethoxy-benzoic acid
• CAS No.: 119680-49-8
• Molecular Formula: C₁₇H₂₂O₈
• Molecular Weight: 354.357
• Mol file: 119680-49-8.mol

Synonyms:2-((S)-4-Carboxy-1-methyl-butoxycarbonylmethyl)-4,6-dimethoxy-benzoic acid

Chemical Property of 2-((S)-4-Carboxy-1-methyl-butoxycarbonylmethyl)-4,6-dimethoxy-benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((S)-4-Carboxy-1-methyl-butoxycarbonylmethyl)-4,6-dimethoxy-benzoic acid

There total 1 articles about 2-((S)-4-Carboxy-1-methyl-butoxycarbonylmethyl)-4,6-dimethoxy-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

(S,E)-11,13-dimethoxy-4-methyl-4,5,6,7-tetrahydro-1H-benzo[d][1]oxacyclododecine-2,10-dione (100905-80-4) → 2-((S)-4-Carboxy-1-methyl-butoxycarbonylmethyl)-4,6-dimethoxy-benzoic acid (119680-49-8) + (S)-5-[2-(3,5-Dimethoxy-2-oxalyl-phenyl)-acetoxy]-hexanoic acid (119680-50-1)

Guidance literature:

With potassium permanganate; sodium periodate; potassium carbonate; In water; tert-butyl alcohol; at 20 ℃; for 120h;

DOI:10.1021/ja00191a042

Reference yield: 39.0%

(S)-Methyl mandelate (21210-43-5) + 2-((S)-4-Carboxy-1-methyl-butoxycarbonylmethyl)-4,6-dimethoxy-benzoic acid (119680-49-8) → (S)-5-(6,8-Dimethoxy-1-oxo-1H-isochromen-3-yloxy)-hexanoic acid (S)-methoxycarbonyl-phenyl-methyl ester (119680-51-2)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 16h; Ambient temperature;

DOI:10.1021/ja00191a042

Reference yield: 39.0%

2-((S)-4-Carboxy-1-methyl-butoxycarbonylmethyl)-4,6-dimethoxy-benzoic acid (119680-49-8) → (S)-6-methyl-tetrahydro-pyran-2-one (16320-13-1)

Guidance literature:

With potassium tert-butylate; water; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/ja00191a042

upstream raw materials:

(S,E)-11,13-dimethoxy-4-methyl-4,5,6,7-tetrahydro-1H-benzo[d][1]oxacyclododecine-2,10-dione

Downstream raw materials:

(S)-5-(6,8-Dimethoxy-1-oxo-1H-isochromen-3-yloxy)-hexanoic acid (S)-methoxycarbonyl-phenyl-methyl ester

(S)-6-methyl-tetrahydro-pyran-2-one