((2-Methoxyphenyl)methyl)oxirane

Base Information

• Chemical Name: ((2-Methoxyphenyl)methyl)oxirane
• CAS No.: 62826-28-2
• Molecular Formula: C10H12O2
• Molecular Weight: 164.2
• Hs Code.: 2910900090
• UNII: SB0IGZ426C
• DSSTox Substance ID: DTXSID50978528
• Nikkaji Number: J2.545.406E
• Wikidata: Q27289121
• Mol file: 62826-28-2.mol

Synonyms:2-(2-Methoxybenzyl)oxirane;62826-28-2;((2-Methoxyphenyl)methyl)oxirane;o-Methoxyphenylpropylene oxide;2-[(2-methoxyphenyl)methyl]oxirane;Oxirane, 2-((2-methoxyphenyl)methyl)-;SB0IGZ426C;2-Allylmethoxybenzene oxide;Oxirane, 2-[(2-methoxyphenyl)methyl]-;CCRIS 1152;UNII-SB0IGZ426C;BRN 4937695;SCHEMBL7114249;DTXSID50978528;MFCD01747980;AKOS006276839;2-ALLYL-1-METHOXYBENZENE OXIDE;2-METHOXY-1-(OXIRANYLMETHYL)BENZENE;CS-0454385;OXIRANE, ((2-METHOXYPHENYL)METHYL)-;EN300-196349;Q27289121

Chemical Property of ((2-Methoxyphenyl)methyl)oxirane

Chemical Property:

• Vapor Pressure: 0.0518mmHg at 25°C
• Boiling Point: 242.8°C at 760 mmHg
• Flash Point: 94.3°C
• PSA: 21.76000
• Density: 1.12g/cm³
• LogP: 1.63650
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 164.083729621
• Heavy Atom Count: 12
• Complexity: 147

Purity/Quality:

99% ^*data from raw suppliers

2-(2-methoxybenzyl)oxirane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1CC2CO2

Technology Process of ((2-Methoxyphenyl)methyl)oxirane

There total 1 articles about ((2-Methoxyphenyl)methyl)oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-allylanisole (3698-28-0) → (2-methoxy-benzyl)-oxirane (62826-28-2)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 - 25 ℃; for 4h;

DOI:10.1021/jm00373a003

Reference yield: 61.0%

(2-methoxy-benzyl)-oxirane (62826-28-2) + 3-acetoxy-2-methylene-3-phenylpropionitrile (138597-12-3,144299-84-3,144370-28-5,143165-00-8) → (2Z)-2-benzylidene-5-hydroxy-4-(2-methoxybenzyl)pentanenitrile

Guidance literature:

(2-methoxy-benzyl)-oxirane; 3-acetoxy-2-methylene-3-phenylpropionitrile; In tetrahydrofuran; at 20 ℃;

With sulfuric acid; In tetrahydrofuran; at 20 ℃; Further stages.;

DOI:10.1021/jo800049p

Reference yield: 61.0%

(2-methoxy-benzyl)-oxirane (62826-28-2) + methyl 2-(acetoxy(4-methylphenyl)methyl)acrylate (143165-01-9) → (3E)-5-(2-methoxybenzyl)-3-(4-methylbenzylidene)tetrahydro-2H-pyran-2-one (1026729-62-3)

Guidance literature:

(2-methoxy-benzyl)-oxirane; methyl 2-(acetoxy(4-methylphenyl)methyl)acrylate; In tetrahydrofuran; at 20 ℃;

With sulfuric acid; In tetrahydrofuran; at 20 ℃; Further stages.;

DOI:10.1021/jo800049p

upstream raw materials:

2-allylanisole

Downstream raw materials:

5-(2-methoxy-benzyl)-oxazolidin-2-one

5-(2-{Benzyl-[2-hydroxy-3-(2-methoxy-phenyl)-propyl]-amino}-ethoxy)-2-hydroxy-benzamide

(2-methoxy-phenyl)-acetaldehyde

4-hydroxy-5-(o-methoxyphenyl)pent-1-ene

Refernces

• 1、 Fuhrer,Ostermayer,Zimmermann,Meier,Mueller. "β-Adrenergic blocking agents: Substituted phenylalkanolamines. Effect of side-chain length on β-blocking potency in vitro". . p. 831 - 836. Retrieved 2007/10/02.