((R)-(3-benzyl-3-methyl-2,3-dihydro-benzofuran-6-yl)-piperidin-1-yl-methanone)

Base Information

Chemical Name:((R)-(3-benzyl-3-methyl-2,3-dihydro-benzofuran-6-yl)-piperidin-1-yl-methanone)
CAS No.:1196995-96-6
Molecular Formula:C₂₂H₂₅NO₂
Molecular Weight:335.446
Hs Code.:

Synonyms:((R)-(3-benzyl-3-methyl-2,3-dihydro-benzofuran-6-yl)-piperidin-1-yl-methanone)

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Chemical Property of ((R)-(3-benzyl-3-methyl-2,3-dihydro-benzofuran-6-yl)-piperidin-1-yl-methanone)

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Technology Process of ((R)-(3-benzyl-3-methyl-2,3-dihydro-benzofuran-6-yl)-piperidin-1-yl-methanone)

There total 15 articles about ((R)-(3-benzyl-3-methyl-2,3-dihydro-benzofuran-6-yl)-piperidin-1-yl-methanone) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 110-89-4
piperidine

: (R)-3-benzyl-3-methyl-2,3-dihydro-benzofuran-6-carboxylic acid

: 1196995-96-6
((R)-(3-benzyl-3-methyl-2,3-dihydro-benzofuran-6-yl)-piperidin-1-yl-methanone)

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 23 ℃; for 16h; optical yield given as %ee;
DOI:10.1016/j.tetlet.2012.04.076

Reference yield: 87.0%

: (R)-3-benzyl-3-methyl-6-(piperidine-1-carbonyl)-2,3-dihydrobenzofuran-4-carbaldehyde

: 1196995-96-6
((R)-(3-benzyl-3-methyl-2,3-dihydro-benzofuran-6-yl)-piperidin-1-yl-methanone)

Guidance literature:: With Wilkinson's catalyst; In toluene; at 120 ℃; for 36h; Inert atmosphere; Sealed tube;
DOI:10.1002/anie.201913733

Reference yield: 85.0%

: C₂₂H₂₄INO₂

: 1196995-96-6
((R)-(3-benzyl-3-methyl-2,3-dihydro-benzofuran-6-yl)-piperidin-1-yl-methanone)

Guidance literature:: With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; (S)-N-((R)-(3,5-di-tert-butyl-4-methoxyphenyl)(2-(dicyclohexylphosphanyl)phenyl)methyl)-N,2-dimethylpropane-2-sulfinamide; sodium formate; In methanol; toluene; at 85 ℃; for 40h; enantioselective reaction; Inert atmosphere; Sealed tube;
DOI:10.1002/anie.201806372