3-benzyl-6-(piperidine-1-carbonyl)-2,3-dihydro-benzofuran-3-carboxylic acid methyl ester

Base Information

Chemical Name:3-benzyl-6-(piperidine-1-carbonyl)-2,3-dihydro-benzofuran-3-carboxylic acid methyl ester
CAS No.:1380595-49-2
Molecular Formula:C₂₃H₂₅NO₄
Molecular Weight:379.456
Hs Code.:

Synonyms:3-benzyl-6-(piperidine-1-carbonyl)-2,3-dihydro-benzofuran-3-carboxylic acid methyl ester

Suppliers and Price of 3-benzyl-6-(piperidine-1-carbonyl)-2,3-dihydro-benzofuran-3-carboxylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 3-benzyl-6-(piperidine-1-carbonyl)-2,3-dihydro-benzofuran-3-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-benzyl-6-(piperidine-1-carbonyl)-2,3-dihydro-benzofuran-3-carboxylic acid methyl ester

There total 3 articles about 3-benzyl-6-(piperidine-1-carbonyl)-2,3-dihydro-benzofuran-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1380595-48-1
C₁₇H₂₀INO₄

: 98-80-6
phenylboronic acid

: 1380595-49-2
3-benzyl-6-(piperidine-1-carbonyl)-2,3-dihydro-benzofuran-3-carboxylic acid methyl ester

Guidance literature:: With tetrabutyl-ammonium chloride; palladium diacetate; potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 16h;
DOI:10.1016/j.tetlet.2012.04.076

Reference yield:

: 58123-77-6
3-hydroxy-4-iodobenzoic acid

: 1380595-49-2
3-benzyl-6-(piperidine-1-carbonyl)-2,3-dihydro-benzofuran-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 23 °C

2: potassium carbonate / butanone / 3 h / Reflux

3: tetrabutyl-ammonium chloride; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C

With tetrabutyl-ammonium chloride; palladium diacetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; butanone;
DOI:10.1016/j.tetlet.2012.04.076

Reference yield:

: 110-89-4
piperidine

: 1380595-49-2
3-benzyl-6-(piperidine-1-carbonyl)-2,3-dihydro-benzofuran-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 23 °C

2: potassium carbonate / butanone / 3 h / Reflux

3: tetrabutyl-ammonium chloride; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C

With tetrabutyl-ammonium chloride; palladium diacetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; butanone;
DOI:10.1016/j.tetlet.2012.04.076