(1R,3S)-tert-butyl (3-(1-(4-(1-(4-(cyclopropylmethoxy)phenyl)pyrrolidin-3-yloxy)phenyl)ethylcarbamoyl)cyclopentyl)carbamate

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Chemical Name:(1R,3S)-tert-butyl (3-(1-(4-(1-(4-(cyclopropylmethoxy)phenyl)pyrrolidin-3-yloxy)phenyl)ethylcarbamoyl)cyclopentyl)carbamate
CAS No.:1594131-15-3
Molecular Formula:C₃₃H₄₅N₃O₅
Molecular Weight:563.737
Hs Code.:

Synonyms:(1R,3S)-tert-butyl (3-(1-(4-(1-(4-(cyclopropylmethoxy)phenyl)pyrrolidin-3-yloxy)phenyl)ethylcarbamoyl)cyclopentyl)carbamate

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Chemical Property of (1R,3S)-tert-butyl (3-(1-(4-(1-(4-(cyclopropylmethoxy)phenyl)pyrrolidin-3-yloxy)phenyl)ethylcarbamoyl)cyclopentyl)carbamate

Chemical Property:

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Technology Process of (1R,3S)-tert-butyl (3-(1-(4-(1-(4-(cyclopropylmethoxy)phenyl)pyrrolidin-3-yloxy)phenyl)ethylcarbamoyl)cyclopentyl)carbamate

There total 5 articles about (1R,3S)-tert-butyl (3-(1-(4-(1-(4-(cyclopropylmethoxy)phenyl)pyrrolidin-3-yloxy)phenyl)ethylcarbamoyl)cyclopentyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1594130-80-9
(S)-1-(4-((R)-1-(4-cyclopropylmethoxyphenyl)-pyrrolidin-3-yloxy)-phenyl)ethanamine hydrochloride

: 261165-05-3
(1S,3R)-3-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid

: 1594131-15-3
(1R,3S)-tert-butyl (3-(1-(4-(1-(4-(cyclopropylmethoxy)phenyl)pyrrolidin-3-yloxy)phenyl)ethylcarbamoyl)cyclopentyl)carbamate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: (S)-1-(4-((R)-1-(4-cyclopropylmethoxyphenyl)pyrrolidin-3-yloxy)phenyl)ethanamine hydrochloride

: 261165-05-3
(1S,3R)-3-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid

: 1594131-15-3
(1R,3S)-tert-butyl (3-(1-(4-(1-(4-(cyclopropylmethoxy)phenyl)pyrrolidin-3-yloxy)phenyl)ethylcarbamoyl)cyclopentyl)carbamate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1594129-66-4
C₂₅H₃₂N₂O₅

: 1594131-15-3
(1R,3S)-tert-butyl (3-(1-(4-(1-(4-(cyclopropylmethoxy)phenyl)pyrrolidin-3-yloxy)phenyl)ethylcarbamoyl)cyclopentyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2250.23 Torr

2: sodium t-butanolate; chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) / 1,4-dioxane / 15 h / 20 °C / Inert atmosphere

3: ethanol / 20 °C

4: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); palladium 10% on activated carbon; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; In 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide;