(S)-1-(4-((R)-1-(4-cyclopropylmethoxyphenyl)-pyrrolidin-3-yloxy)-phenyl)ethanamine hydrochloride

Base Information

Chemical Name:(S)-1-(4-((R)-1-(4-cyclopropylmethoxyphenyl)-pyrrolidin-3-yloxy)-phenyl)ethanamine hydrochloride
CAS No.:1594130-80-9
Molecular Formula:C₂₂H₂₈N₂O₂*ClH
Molecular Weight:388.937
Hs Code.:

Synonyms:(S)-1-(4-((R)-1-(4-cyclopropylmethoxyphenyl)-pyrrolidin-3-yloxy)-phenyl)ethanamine hydrochloride

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Chemical Property of (S)-1-(4-((R)-1-(4-cyclopropylmethoxyphenyl)-pyrrolidin-3-yloxy)-phenyl)ethanamine hydrochloride

Chemical Property:

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Technology Process of (S)-1-(4-((R)-1-(4-cyclopropylmethoxyphenyl)-pyrrolidin-3-yloxy)-phenyl)ethanamine hydrochloride

There total 3 articles about (S)-1-(4-((R)-1-(4-cyclopropylmethoxyphenyl)-pyrrolidin-3-yloxy)-phenyl)ethanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7647-01-0,15364-23-5
hydrogenchloride

: 1594130-78-5
C₂₇H₃₆N₂O₄

: 1594130-80-9
(S)-1-(4-((R)-1-(4-cyclopropylmethoxyphenyl)-pyrrolidin-3-yloxy)-phenyl)ethanamine hydrochloride

Guidance literature:: In ethanol; at 20 ℃;

Reference yield:

: 1594129-66-4
C₂₅H₃₂N₂O₅

: 1594130-80-9
(S)-1-(4-((R)-1-(4-cyclopropylmethoxyphenyl)-pyrrolidin-3-yloxy)-phenyl)ethanamine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2250.23 Torr

2: sodium t-butanolate; chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) / 1,4-dioxane / 15 h / 20 °C / Inert atmosphere

3: ethanol / 20 °C

With chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); palladium 10% on activated carbon; hydrogen; sodium t-butanolate; In 1,4-dioxane; methanol; ethanol;

Reference yield:

: tert-butyl ((S)-1-(4-((R)-pyrrolidin-3-yloxy)phenyl)ethyl)carbamate

: 1594130-80-9
(S)-1-(4-((R)-1-(4-cyclopropylmethoxyphenyl)-pyrrolidin-3-yloxy)-phenyl)ethanamine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium t-butanolate; chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) / 1,4-dioxane / 15 h / 20 °C / Inert atmosphere

2: ethanol / 20 °C

With chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); sodium t-butanolate; In 1,4-dioxane; ethanol;