(1R,4S)-1-hydroxy-4-<oxy>-1-phenyl-3-pentanone

Base Information

Chemical Name:(1R,4S)-1-hydroxy-4-<oxy>-1-phenyl-3-pentanone
CAS No.:219701-11-8
Molecular Formula:C₁₇H₂₈O₃Si
Molecular Weight:308.493
Hs Code.:

(1R,4S)-1-hydroxy-4-<<dimethyl(1,1-dimethylethyl)silyl>oxy>-1-phenyl-3-pentanone

Synonyms:(1R,4S)-1-hydroxy-4-<oxy>-1-phenyl-3-pentanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,4S)-1-hydroxy-4-<oxy>-1-phenyl-3-pentanone

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Technology Process of (1R,4S)-1-hydroxy-4-<oxy>-1-phenyl-3-pentanone

There total 11 articles about (1R,4S)-1-hydroxy-4-<oxy>-1-phenyl-3-pentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.7%

: 100-52-7
benzaldehyde

: 219584-40-4
(-)-(S)-<<1-<oxy>ethyl>ethenyl>oxytrimethylsilane

: (1S,4S)-1-hydroxy-4-<oxy>-1-phenyl-3-pentanone

: 219701-11-8
(1R,4S)-1-hydroxy-4-<oxy>-1-phenyl-3-pentanone

Guidance literature:: (-)-(S)-<<1-<oxy>ethyl>ethenyl>oxytrimethylsilane; With tetrachlorosilane; mercury(II) diacetate; In dichloromethane; at 20 ℃; for 1.5h;

benzaldehyde; With (S,S)-N,N'-dimethylstilbene-1,2-diamine chiral phosphoramide; In dichloromethane; at -75 ℃; for 3h; Further stages.;
DOI:10.1021/ja001023g

Reference yield:

: 100-52-7
benzaldehyde

: 167777-72-2
(-)-S-3-<oxy>-2-butanone

: (1S,4S)-1-hydroxy-4-<oxy>-1-phenyl-3-pentanone

: 219701-11-8
(1R,4S)-1-hydroxy-4-<oxy>-1-phenyl-3-pentanone

Guidance literature:: (-)-S-3-<oxy>-2-butanone; With titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -94 ℃; Inert atmosphere;

benzaldehyde; In dichloromethane; at -78 ℃; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tetlet.2009.12.046

Reference yield:

: 100-52-7
benzaldehyde

: 3-(tert-butyl-dimethyl-silanyloxy)-2-trichlorosilanyloxy-but-1-ene

: (1S,4S)-1-hydroxy-4-<oxy>-1-phenyl-3-pentanone

: 219701-11-8
(1R,4S)-1-hydroxy-4-<oxy>-1-phenyl-3-pentanone

Guidance literature:: 3-(tert-butyl-dimethyl-silanyloxy)-2-trichlorosilanyloxy-but-1-ene; With tetrachlorosilane; mercury(II) diacetate; In dichloromethane; at 20 ℃; for 1h;

benzaldehyde; In dichloromethane; at 20 ℃; for 9h; Further stages.;
DOI:10.1021/ja001023g