(4-Benzyloxy-1-methyl-1,2,3,6-tetrahydro-pyridin-2-yl)-methanethiol

Base Information

Chemical Name:(4-Benzyloxy-1-methyl-1,2,3,6-tetrahydro-pyridin-2-yl)-methanethiol
CAS No.:175849-34-0
Molecular Formula:C₁₄H₁₉NOS
Molecular Weight:249.377
Hs Code.:

Synonyms:(4-Benzyloxy-1-methyl-1,2,3,6-tetrahydro-pyridin-2-yl)-methanethiol

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Chemical Property of (4-Benzyloxy-1-methyl-1,2,3,6-tetrahydro-pyridin-2-yl)-methanethiol

Chemical Property:

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Technology Process of (4-Benzyloxy-1-methyl-1,2,3,6-tetrahydro-pyridin-2-yl)-methanethiol

There total 8 articles about (4-Benzyloxy-1-methyl-1,2,3,6-tetrahydro-pyridin-2-yl)-methanethiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5470-66-6
2-methyl-4-nitropyridine N-oxide

: 175849-34-0
(4-Benzyloxy-1-methyl-1,2,3,6-tetrahydro-pyridin-2-yl)-methanethiol

Guidance literature:: Multi-step reaction with 6 steps

1: 52 percent / PhCH₂OH / 80 °C

2: conc. H₂SO₄ / 1.) 110 deg C, 3 h, 2.) room temperature, overnight

3: K₂CO₃ / methanol; H₂O / 0.25 h

4: 95 percent / PPh₃, DEAD / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) room temperature, 1 h

5: acetone / 1.) room temperature, 2.5 h, 2.) reflux, 1 h

6: 1.) NaBH₄, 2.) LiAlH₄ / 1.) MeOH, reflux, 30 min, 2.) THF, 0 deg C, 10 min

With sodium tetrahydroborate; lithium aluminium tetrahydride; sulfuric acid; potassium carbonate; triphenylphosphine; benzyl alcohol; diethylazodicarboxylate; In tetrahydrofuran; methanol; water; acetone;
DOI:10.1021/jo951995k

Reference yield:

: 931-19-1
2-methylpyridine N-oxide

: 175849-34-0
(4-Benzyloxy-1-methyl-1,2,3,6-tetrahydro-pyridin-2-yl)-methanethiol

Guidance literature:: Multi-step reaction with 7 steps

1: 76 percent / HNO₃, H₂SO₄ / 16 h / 85 - 95 °C

2: 52 percent / PhCH₂OH / 80 °C

3: conc. H₂SO₄ / 1.) 110 deg C, 3 h, 2.) room temperature, overnight

4: K₂CO₃ / methanol; H₂O / 0.25 h

5: 95 percent / PPh₃, DEAD / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) room temperature, 1 h

6: acetone / 1.) room temperature, 2.5 h, 2.) reflux, 1 h

7: 1.) NaBH₄, 2.) LiAlH₄ / 1.) MeOH, reflux, 30 min, 2.) THF, 0 deg C, 10 min

With sodium tetrahydroborate; lithium aluminium tetrahydride; sulfuric acid; nitric acid; potassium carbonate; triphenylphosphine; benzyl alcohol; diethylazodicarboxylate; In tetrahydrofuran; methanol; water; acetone;
DOI:10.1021/jo951995k

Reference yield:

: 63071-11-4
4-(benzyloxy)-2-(hydroxymethyl)pyridine

: 175849-34-0
(4-Benzyloxy-1-methyl-1,2,3,6-tetrahydro-pyridin-2-yl)-methanethiol

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / PPh₃, DEAD / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) room temperature, 1 h

2: acetone / 1.) room temperature, 2.5 h, 2.) reflux, 1 h

3: 1.) NaBH₄, 2.) LiAlH₄ / 1.) MeOH, reflux, 30 min, 2.) THF, 0 deg C, 10 min

With sodium tetrahydroborate; lithium aluminium tetrahydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; acetone;
DOI:10.1021/jo951995k