Technology Process of N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-N,2-dimethylbenzamide
There total 6 articles about N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-N,2-dimethylbenzamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-(2-(1-benzyl-1H-1, 2, 3-triazol-4-yl)propan-2-yl)-2-methylbenzamide;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 0 - 20 ℃;
for 1h;
Inert atmosphere;
Schlenk technique;
methyl iodide;
In
tetrahydrofuran; mineral oil;
at 0 - 20 ℃;
for 16h;
DOI:10.1002/anie.201311024
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 24 h / 20 °C / Inert atmosphere; Schlenk technique
2.1: N,N-dimethyl-formamide / dichloromethane / 5 h / 0 °C / Inert atmosphere; Schlenk technique
2.2: 12 h / 0 - 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere; Schlenk technique
3.2: 16 h / 0 - 20 °C
With
copper(ll) sulfate pentahydrate; sodium hydride; sodium L-ascorbate; N,N-dimethyl-formamide;
In
tetrahydrofuran; dichloromethane; water; mineral oil; tert-butyl alcohol;
DOI:10.1002/anie.201311024
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 24 h / 20 °C / Inert atmosphere; Schlenk technique
2.1: N,N-dimethyl-formamide / dichloromethane / 5 h / 0 °C / Inert atmosphere; Schlenk technique
2.2: 12 h / 0 - 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere; Schlenk technique
3.2: 16 h / 0 - 20 °C
With
copper(ll) sulfate pentahydrate; sodium hydride; sodium L-ascorbate; N,N-dimethyl-formamide;
In
tetrahydrofuran; dichloromethane; water; mineral oil; tert-butyl alcohol;
DOI:10.1002/anie.201311024
