trans-ethyl 4-((1-(5-(5-chloro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

Base Information

Chemical Name:trans-ethyl 4-((1-(5-(5-chloro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate
CAS No.:1415571-50-4
Molecular Formula:C₂₆H₃₁ClN₄O₃
Molecular Weight:483.01
Hs Code.:

Synonyms:trans-ethyl 4-((1-(5-(5-chloro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

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Chemical Property of trans-ethyl 4-((1-(5-(5-chloro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

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Technology Process of trans-ethyl 4-((1-(5-(5-chloro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

There total 6 articles about trans-ethyl 4-((1-(5-(5-chloro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372092-49-3
5-chloro-2-(6-fluoropyridin-3-yl)-1H-benzo[d]imidazole

: 1415573-48-6
trans ethyl 4-(piperidin-4-yloxy)cyclohexanecarboxylate

: 1415571-50-4
trans-ethyl 4-((1-(5-(5-chloro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

Guidance literature:: With sodium hydrogencarbonate; In dimethyl sulfoxide; at 110 ℃; Inert atmosphere;
DOI:10.1021/ml5003426

Reference yield:

: 677728-92-6
2-fluoro-5-formylpyridine

: 1415571-50-4
trans-ethyl 4-((1-(5-(5-chloro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: Oxone / N,N-dimethyl acetamide; water / 0 - 20 °C

2: sodium hydrogencarbonate / dimethyl sulfoxide / 110 °C / Inert atmosphere

With Oxone; sodium hydrogencarbonate; In N,N-dimethyl acetamide; water; dimethyl sulfoxide;
DOI:10.1021/ml5003426

Reference yield:

: 3618-04-0,75877-66-6,17159-80-7
4-hydroxycyclohexyl carboxylic acid ethyl ester

: 1415571-50-4
trans-ethyl 4-((1-(5-(5-chloro-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 48 h / 20 - 55 °C / Inert atmosphere

2: platinum(IV) oxide; toluene-4-sulfonic acid; hydrogen / ethanol / 120 h / 20 °C / 2327.23 Torr / Inert atmosphere

3: sodium hydrogencarbonate / dimethyl sulfoxide / 110 °C / Inert atmosphere

With platinum(IV) oxide; di-isopropyl azodicarboxylate; hydrogen; sodium hydrogencarbonate; toluene-4-sulfonic acid; triphenylphosphine; In tetrahydrofuran; ethanol; dimethyl sulfoxide;
DOI:10.1021/ml5003426