(2-(Bis-(4-fluorophenyl)methyl)-4-trifluoromethanesulfonyloxythiazol-5-yl)acetic acid

Base Information

Chemical Name:(2-(Bis-(4-fluorophenyl)methyl)-4-trifluoromethanesulfonyloxythiazol-5-yl)acetic acid
CAS No.:939437-25-9
Molecular Formula:C₁₉H₁₂F₅NO₅S₂
Molecular Weight:493.432
Hs Code.:

Synonyms:(2-(Bis-(4-fluorophenyl)methyl)-4-trifluoromethanesulfonyloxythiazol-5-yl)acetic acid

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Chemical Property of (2-(Bis-(4-fluorophenyl)methyl)-4-trifluoromethanesulfonyloxythiazol-5-yl)acetic acid

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Technology Process of (2-(Bis-(4-fluorophenyl)methyl)-4-trifluoromethanesulfonyloxythiazol-5-yl)acetic acid

There total 1 articles about (2-(Bis-(4-fluorophenyl)methyl)-4-trifluoromethanesulfonyloxythiazol-5-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 939437-24-8
(2-(Bis-(4-fluorophenyl)methyl)-4-hydroxythiazol-5-yl)acetic acid

: 358-23-6
trifluoromethylsulfonic anhydride

: 939437-25-9
(2-(Bis-(4-fluorophenyl)methyl)-4-trifluoromethanesulfonyloxythiazol-5-yl)acetic acid

Guidance literature:: In dichloromethane;
DOI:10.1016/j.bmcl.2009.12.015

Reference yield: 56.0%

: 939437-25-9
(2-(Bis-(4-fluorophenyl)methyl)-4-trifluoromethanesulfonyloxythiazol-5-yl)acetic acid

: 401815-98-3
2-fluoropyridin-4-ylboronic acid

: 939437-27-1
[2-[Bis-(4-fluorophenyl)methyl]-4-(2-fluoropyridin-4-yl)thiazol-5-yl]acetic acid

Guidance literature:: (2-(Bis-(4-fluorophenyl)methyl)-4-trifluoromethanesulfonyloxythiazol-5-yl)acetic acid; 2-fluoropyridin-4-ylboronic acid; With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 90 ℃; for 2h;

With hydrogenchloride; In 1,4-dioxane; water;

Reference yield: 27.0%

: 939437-25-9
(2-(Bis-(4-fluorophenyl)methyl)-4-trifluoromethanesulfonyloxythiazol-5-yl)acetic acid

: 579476-63-4
2-methylpyridine-4-boronic acid

: 939437-26-0
[2-[Bis-(4-fluoro-phenyl)methyl]-4-(2-methylpyridin-4-yl)thiazol-5-yl]acetic acid

Guidance literature:: (2-(Bis-(4-fluorophenyl)methyl)-4-trifluoromethanesulfonyloxythiazol-5-yl)acetic acid; 2-methylpyridine-4-boronic acid; With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 80 ℃;

With hydrogenchloride; In 1,4-dioxane; water;