[2-[Bis-(4-fluorophenyl)methyl]-4-(2-fluoropyridin-4-yl)thiazol-5-yl]acetic acid

Base Information

Chemical Name:[2-[Bis-(4-fluorophenyl)methyl]-4-(2-fluoropyridin-4-yl)thiazol-5-yl]acetic acid
CAS No.:939437-27-1
Molecular Formula:C₂₃H₁₅F₃N₂O₂S
Molecular Weight:440.446
Hs Code.:

Synonyms:[2-[Bis-(4-fluorophenyl)methyl]-4-(2-fluoropyridin-4-yl)thiazol-5-yl]acetic acid

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Chemical Property of [2-[Bis-(4-fluorophenyl)methyl]-4-(2-fluoropyridin-4-yl)thiazol-5-yl]acetic acid

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Technology Process of [2-[Bis-(4-fluorophenyl)methyl]-4-(2-fluoropyridin-4-yl)thiazol-5-yl]acetic acid

There total 1 articles about [2-[Bis-(4-fluorophenyl)methyl]-4-(2-fluoropyridin-4-yl)thiazol-5-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 939437-25-9
(2-(Bis-(4-fluorophenyl)methyl)-4-trifluoromethanesulfonyloxythiazol-5-yl)acetic acid

: 401815-98-3
2-fluoropyridin-4-ylboronic acid

: 939437-27-1
[2-[Bis-(4-fluorophenyl)methyl]-4-(2-fluoropyridin-4-yl)thiazol-5-yl]acetic acid

Guidance literature:: (2-(Bis-(4-fluorophenyl)methyl)-4-trifluoromethanesulfonyloxythiazol-5-yl)acetic acid; 2-fluoropyridin-4-ylboronic acid; With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 90 ℃; for 2h;

With hydrogenchloride; In 1,4-dioxane; water;

Reference yield: 29.0%

: 123-75-1
pyrrolidine

: 939437-27-1
[2-[Bis-(4-fluorophenyl)methyl]-4-(2-fluoropyridin-4-yl)thiazol-5-yl]acetic acid

: 1214879-79-4
C₂₇H₂₃F₂N₃O₂S

Guidance literature:: at 90 ℃; Neat (no solvent);
DOI:10.1016/j.bmcl.2009.12.015

Reference yield: 16.0%

: 939437-27-1
[2-[Bis-(4-fluorophenyl)methyl]-4-(2-fluoropyridin-4-yl)thiazol-5-yl]acetic acid

: 939437-28-2
{4-(2-Aminopyridin-4-yl)-2-[bis-(4-fluorophenyl)methyl]thiazol-5-yl}acetic acid

Guidance literature:: [2-[Bis-(4-fluorophenyl)methyl]-4-(2-fluoropyridin-4-yl)thiazol-5-yl]acetic acid; With ammonium hydroxide; In water; at 90 ℃; for 168h;

With hydrogenchloride; In dichloromethane; water;