(E)-ethyl 3-(3-(4-methoxyphenyl)allyl)-2,4-dioxo-5-phenethyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxylate

Base Information

Chemical Name:(E)-ethyl 3-(3-(4-methoxyphenyl)allyl)-2,4-dioxo-5-phenethyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxylate
CAS No.:1376709-52-2
Molecular Formula:C₂₇H₂₆N₂O₅S
Molecular Weight:490.58
Hs Code.:

Synonyms:(E)-ethyl 3-(3-(4-methoxyphenyl)allyl)-2,4-dioxo-5-phenethyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxylate

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Chemical Property of (E)-ethyl 3-(3-(4-methoxyphenyl)allyl)-2,4-dioxo-5-phenethyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxylate

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Technology Process of (E)-ethyl 3-(3-(4-methoxyphenyl)allyl)-2,4-dioxo-5-phenethyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxylate

There total 7 articles about (E)-ethyl 3-(3-(4-methoxyphenyl)allyl)-2,4-dioxo-5-phenethyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1376709-62-4
(E)-diethyl 5-(3-(3-(4-methoxyphenyl)allyl)ureido)-3-phenethylthiophene-2,4-dicarboxylate

: 1376709-52-2
(E)-ethyl 3-(3-(4-methoxyphenyl)allyl)-2,4-dioxo-5-phenethyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxylate

Guidance literature:: With sodium methylate; In methanol; for 3h; Reflux;
DOI:10.1016/j.ejmech.2012.02.035

Reference yield:

: 14482-11-2
(E)-p-methoxycinnamonitrile

: 1376709-52-2
(E)-ethyl 3-(3-(4-methoxyphenyl)allyl)-2,4-dioxo-5-phenethyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / diethyl ether / 0.67 h / 20 °C

2: pyridine; dmap / tetrahydrofuran / 12 h / 20 °C

3: sodium methylate / methanol / 3 h / Reflux

With pyridine; dmap; lithium aluminium tetrahydride; sodium methylate; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1016/j.ejmech.2012.02.035

Reference yield:

: 1376709-57-7
diethyl 5-amino-3-phenethylthiophene-2,4-dicarboxylate

: 1376709-52-2
(E)-ethyl 3-(3-(4-methoxyphenyl)allyl)-2,4-dioxo-5-phenethyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 18.25 h / 20 °C

2: pyridine; dmap / tetrahydrofuran / 12 h / 20 °C

3: sodium methylate / methanol / 3 h / Reflux

With pyridine; dmap; sodium methylate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.ejmech.2012.02.035