diethyl 5-((4-nitrophenoxy)carbonylamino)-3-phenethylthiophene-2,4-dicarboxylate

Base Information

Chemical Name:diethyl 5-((4-nitrophenoxy)carbonylamino)-3-phenethylthiophene-2,4-dicarboxylate
CAS No.:1376709-58-8
Molecular Formula:C₂₅H₂₄N₂O₈S
Molecular Weight:512.54
Hs Code.:

Synonyms:diethyl 5-((4-nitrophenoxy)carbonylamino)-3-phenethylthiophene-2,4-dicarboxylate

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Chemical Property of diethyl 5-((4-nitrophenoxy)carbonylamino)-3-phenethylthiophene-2,4-dicarboxylate

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Technology Process of diethyl 5-((4-nitrophenoxy)carbonylamino)-3-phenethylthiophene-2,4-dicarboxylate

There total 4 articles about diethyl 5-((4-nitrophenoxy)carbonylamino)-3-phenethylthiophene-2,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1376709-57-7
diethyl 5-amino-3-phenethylthiophene-2,4-dicarboxylate

: 7693-46-1
4-Nitrophenyl chloroformate

: 1376709-58-8
diethyl 5-((4-nitrophenoxy)carbonylamino)-3-phenethylthiophene-2,4-dicarboxylate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 18.25h;
DOI:10.1016/j.ejmech.2012.02.035

Reference yield:

: 100-39-0
benzyl bromide

: 1376709-58-8
diethyl 5-((4-nitrophenoxy)carbonylamino)-3-phenethylthiophene-2,4-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 °C / Inert atmosphere

1.2: 1.5 h / 0 °C / Inert atmosphere

2.1: morpholine; sulfur / ethanol / 48 h / Reflux

3.1: pyridine / dichloromethane / 18.25 h / 20 °C

With morpholine; pyridine; sulfur; n-butyllithium; In tetrahydrofuran; ethanol; hexane; dichloromethane; 2.1: Gewald reaction;
DOI:10.1016/j.ejmech.2012.02.035

Reference yield:

: 1007476-32-5
sodium ethyl acetylacetate enolate

: 1376709-58-8
diethyl 5-((4-nitrophenoxy)carbonylamino)-3-phenethylthiophene-2,4-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 °C / Inert atmosphere

1.2: 1.5 h / 0 °C / Inert atmosphere

2.1: morpholine; sulfur / ethanol / 48 h / Reflux

3.1: pyridine / dichloromethane / 18.25 h / 20 °C

With morpholine; pyridine; sulfur; n-butyllithium; In tetrahydrofuran; ethanol; hexane; dichloromethane; 2.1: Gewald reaction;
DOI:10.1016/j.ejmech.2012.02.035