ethyl 1-(3-chlorophenyl)-5-cyano-4-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate

Base Information

• Chemical Name: ethyl 1-(3-chlorophenyl)-5-cyano-4-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate
• CAS No.: 123534-18-9
• Molecular Formula: C₁₅H₁₂ClN₃O₃
• Molecular Weight: 317.732

Synonyms:ethyl 1-(3-chlorophenyl)-5-cyano-4-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate

Chemical Property of ethyl 1-(3-chlorophenyl)-5-cyano-4-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate

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Technology Process of ethyl 1-(3-chlorophenyl)-5-cyano-4-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate

There total 3 articles about ethyl 1-(3-chlorophenyl)-5-cyano-4-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl 2-cyanoacetate (105-56-6) + ethyl 2,3-dioxobutanoate 2-(3-chlorophenyl)hydrazone (20954-21-6) → ethyl 1-(3-chlorophenyl)-5-cyano-4-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate (123534-18-9)

Guidance literature:

With 4-amino-n-butyric acid; at 160 ℃; for 2.5h;

DOI:10.1016/j.bmc.2012.05.027

Reference yield: 80.0%

2-[(3-Chloro-phenyl)-hydrazono]-3-oxo-butyric acid ethyl ester (20954-21-6) + ethyl 2-cyanoacetate (105-56-6) → ethyl 1-(3-chlorophenyl)-5-cyano-4-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate (123534-18-9)

Guidance literature:

With ammonium acetate; at 160 ℃; for 0.5h;

Reference yield:

1-cyano-1,3-diethoxycarbonyl-2-methyl-1-propene (89516-30-3) + 3-chlorobenzenediazonium chloride (100-77-6) → ethyl 1-(3-chlorophenyl)-5-cyano-4-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate (123534-18-9)

Guidance literature:

With sodium acetate; In ethanol; for 0.25h; Yield given; Heating;

upstream raw materials:

1-cyano-1,3-diethoxycarbonyl-2-methyl-1-propene

3-chlorobenzenediazonium chloride

2-[(3-Chloro-phenyl)-hydrazono]-3-oxo-butyric acid ethyl ester

ethyl 2-cyanoacetate

Downstream raw materials:

5-Amino-3-(3-chloro-phenyl)-6-cyano-7-(4-methoxy-phenyl)-4-oxo-3,4-dihydro-phthalazine-1-carboxylic acid ethyl ester

5-Amino-3-(3-chloro-phenyl)-6-cyano-4-oxo-7-phenyl-3,4-dihydro-phthalazine-1-carboxylic acid ethyl ester

5-Amino-3-(3-chloro-phenyl)-7-(4-chloro-phenyl)-6-cyano-4-oxo-3,4-dihydro-phthalazine-1-carboxylic acid ethyl ester

ethyl 5-amino-3-(3-chlorophenyl)-4-oxo-3,4-dihydrothieno-[3,4-d]pyridazine-1-carboxylate

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