4-[[3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenyl]amino]-2,2-dimethyl-4-oxo-butanoic acid

Base Information

Chemical Name:4-[[3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenyl]amino]-2,2-dimethyl-4-oxo-butanoic acid
CAS No.:1447666-93-4
Molecular Formula:C₃₂H₃₈FNO₆
Molecular Weight:551.655
Hs Code.:

Synonyms:4-[[3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenyl]amino]-2,2-dimethyl-4-oxo-butanoic acid

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Chemical Property of 4-[[3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenyl]amino]-2,2-dimethyl-4-oxo-butanoic acid

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Technology Process of 4-[[3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenyl]amino]-2,2-dimethyl-4-oxo-butanoic acid

There total 12 articles about 4-[[3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenyl]amino]-2,2-dimethyl-4-oxo-butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1447667-01-7
4-[[3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propyl-phenyl]amino]-2,2-dimethyl-4-oxo-butanoic acid

: 1447666-93-4
4-[[3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenyl]amino]-2,2-dimethyl-4-oxo-butanoic acid

Guidance literature:: With palladium 10% on activated carbon; In tetrahydrofuran; water; for 88h; under 10343.2 - 46544.6 Torr;

Reference yield:

: 1409654-45-0
tert-butyl 2,3-dimethoxybenzoate

: 1447666-93-4
4-[[3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenyl]amino]-2,2-dimethyl-4-oxo-butanoic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: acetic acid / tetrahydrofuran; diethyl ether / 3.5 h / -12 - -10 °C

2.1: boron tribromide / toluene / 3 h / -25 - -5 °C

2.2: 0.5 h / 7 °C

3.1: thionyl chloride / 35.5 h / -10 °C

4.1: potassium carbonate; dmap / dimethyl sulfoxide / 87 h / 60 °C

5.1: potassium hydroxide / 1-methyl-pyrrolidin-2-one / 0.42 h / 120 °C

6.1: N,N-dimethyl-formamide; thionyl chloride / tetrahydrofuran / 1 h / 0 - 5 °C

6.2: 0.5 h / 0 - 5 °C

7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; N-Bromosuccinimide / methanol / 22 h / -10 - -5 °C

8.1: potassium hydroxide / 1-methyl-pyrrolidin-2-one / 2 h / 110 - 120 °C

9.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 35 °C

10.1: palladium 10% on activated carbon / tetrahydrofuran; water / 88 h / 10343.2 - 46544.6 Torr

With dmap; N-Bromosuccinimide; thionyl chloride; palladium 10% on activated carbon; boron tribromide; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; potassium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; water; dimethyl sulfoxide; toluene;

Reference yield:

: 1447666-95-6
tert-butyl 3-methoxy-2-propylbenzoate

: 1447666-93-4
4-[[3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenyl]amino]-2,2-dimethyl-4-oxo-butanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: boron tribromide / toluene / 3 h / -25 - -5 °C

1.2: 0.5 h / 7 °C

2.1: thionyl chloride / 35.5 h / -10 °C

3.1: potassium carbonate; dmap / dimethyl sulfoxide / 87 h / 60 °C

4.1: potassium hydroxide / 1-methyl-pyrrolidin-2-one / 0.42 h / 120 °C

5.1: N,N-dimethyl-formamide; thionyl chloride / tetrahydrofuran / 1 h / 0 - 5 °C

5.2: 0.5 h / 0 - 5 °C

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; N-Bromosuccinimide / methanol / 22 h / -10 - -5 °C

7.1: potassium hydroxide / 1-methyl-pyrrolidin-2-one / 2 h / 110 - 120 °C

8.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 35 °C

9.1: palladium 10% on activated carbon / tetrahydrofuran; water / 88 h / 10343.2 - 46544.6 Torr

With dmap; N-Bromosuccinimide; thionyl chloride; palladium 10% on activated carbon; boron tribromide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; potassium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; water; dimethyl sulfoxide; toluene;