sodium 4-[[3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenyl]amino]-2,2-dimethyl-4-oxo-butanoate

Base Information

Chemical Name:sodium 4-[[3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenyl]amino]-2,2-dimethyl-4-oxo-butanoate
CAS No.:1447666-94-5
Molecular Formula:C₃₂H₃₇FNO₆*Na
Molecular Weight:573.637
Hs Code.:

Synonyms:sodium 4-[[3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenyl]amino]-2,2-dimethyl-4-oxo-butanoate

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Chemical Property of sodium 4-[[3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenyl]amino]-2,2-dimethyl-4-oxo-butanoate

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Technology Process of sodium 4-[[3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenyl]amino]-2,2-dimethyl-4-oxo-butanoate

There total 13 articles about sodium 4-[[3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenyl]amino]-2,2-dimethyl-4-oxo-butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1447666-93-4
4-[[3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenyl]amino]-2,2-dimethyl-4-oxo-butanoic acid

: 1447666-94-5
sodium 4-[[3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenyl]amino]-2,2-dimethyl-4-oxo-butanoate

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 0.25h;

Reference yield:

: 1447667-01-7
4-[[3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propyl-phenyl]amino]-2,2-dimethyl-4-oxo-butanoic acid

: 1447666-94-5
sodium 4-[[3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenyl]amino]-2,2-dimethyl-4-oxo-butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon / tetrahydrofuran; water / 88 h / 10343.2 - 46544.6 Torr

2: sodium hydroxide / tetrahydrofuran; water / 0.25 h / 20 °C

With palladium 10% on activated carbon; sodium hydroxide; In tetrahydrofuran; water;

Reference yield:

: 1521-38-6
2,3-dimethoxybenzoic acid

: 1447666-94-5
sodium 4-[[3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylphenyl]amino]-2,2-dimethyl-4-oxo-butanoate

Guidance literature:: Multi-step reaction with 13 steps

1.1: N,N-dimethyl-formamide; thionyl chloride / toluene / 1 h / 40 °C

2.1: pyridine; dmap / dichloromethane / 1.08 h / Reflux

3.1: acetic acid / tetrahydrofuran; diethyl ether / 3.5 h / -12 - -10 °C

4.1: boron tribromide / toluene / 3 h / -25 - -5 °C

4.2: 0.5 h / 7 °C

5.1: thionyl chloride / 35.5 h / -10 °C

6.1: potassium carbonate; dmap / dimethyl sulfoxide / 87 h / 60 °C

7.1: potassium hydroxide / 1-methyl-pyrrolidin-2-one / 0.42 h / 120 °C

8.1: N,N-dimethyl-formamide; thionyl chloride / tetrahydrofuran / 1 h / 0 - 5 °C

8.2: 0.5 h / 0 - 5 °C

9.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; N-Bromosuccinimide / methanol / 22 h / -10 - -5 °C

10.1: potassium hydroxide / 1-methyl-pyrrolidin-2-one / 2 h / 110 - 120 °C

11.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 35 °C

12.1: palladium 10% on activated carbon / tetrahydrofuran; water / 88 h / 10343.2 - 46544.6 Torr

13.1: sodium hydroxide / tetrahydrofuran; water / 0.25 h / 20 °C

With pyridine; dmap; N-Bromosuccinimide; thionyl chloride; palladium 10% on activated carbon; boron tribromide; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; toluene;