3-(2',4'-dichlorobenzoyl)cyclopropane-1,1,2,2-tetracarbonitrile

Base Information

• Chemical Name: 3-(2',4'-dichlorobenzoyl)cyclopropane-1,1,2,2-tetracarbonitrile
• CAS No.: 1416564-77-6
• Molecular Formula: C₁₄H₄Cl₂N₄O
• Molecular Weight: 315.118
• Mol file: 1416564-77-6.mol

Synonyms:3-(2',4'-dichlorobenzoyl)cyclopropane-1,1,2,2-tetracarbonitrile

Chemical Property of 3-(2',4'-dichlorobenzoyl)cyclopropane-1,1,2,2-tetracarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-(2',4'-dichlorobenzoyl)cyclopropane-1,1,2,2-tetracarbonitrile

There total 2 articles about 3-(2',4'-dichlorobenzoyl)cyclopropane-1,1,2,2-tetracarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2,4-dichlorophenyl)ethan-1-one (2234-16-4) → 3-(2',4'-dichlorobenzoyl)cyclopropane-1,1,2,2-tetracarbonitrile (1416564-77-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium bromide; sulfuric acid / dimethyl sulfoxide / 85 - 115 °C

2: bromine / water; ethanol / 0.5 h

With sulfuric acid; bromine; sodium bromide; In ethanol; water; dimethyl sulfoxide;

DOI:10.1021/acs.joc.6b01040

Reference yield:

2-oxo-2-(2,4-dichlorophenyl)ethanal (153147-35-4) + malononitrile (109-77-3) → 3-(2',4'-dichlorobenzoyl)cyclopropane-1,1,2,2-tetracarbonitrile (1416564-77-6)

Guidance literature:

With bromine; In ethanol; water; for 0.5h;

DOI:10.1021/acs.joc.6b01040

Reference yield: 83.0%

3-(2',4'-dichlorobenzoyl)cyclopropane-1,1,2,2-tetracarbonitrile (1416564-77-6) → potassium 2-(2',4;-dichlorobenzoyl)-1,1,3,3-tetracyanopropenide

Guidance literature:

3-(2',4'-dichlorobenzoyl)cyclopropane-1,1,2,2-tetracarbonitrile; With potassium acetate; In ethanol; at 45 - 50 ℃;

With potassium chloride; In ethanol; at 5 - 10 ℃; for 0.5h;

DOI:10.1021/acs.joc.6b01040

upstream raw materials:

2-oxo-2-(2,4-dichlorophenyl)ethanal

malononitrile

1-(2,4-dichlorophenyl)ethan-1-one

Downstream raw materials:

4-amino-1-hydroxy-1-(2,4-dichlorophenyl)-3,6-dioxo-2,3,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyridine-7-carbonitrile