1-O-isobutyryl-2-[(tert-butyloxycarbonyl)amino]-3-[N₃-benzoyl(thymin-1-yl)]-L-propanol

Base Information

• Chemical Name: 1-O-isobutyryl-2-[(tert-butyloxycarbonyl)amino]-3-[N₃-benzoyl(thymin-1-yl)]-L-propanol
• CAS No.: 179472-14-1
• Molecular Formula: C₂₄H₃₁N₃O₇
• Molecular Weight: 473.526

Synonyms:1-O-isobutyryl-2-[(tert-butyloxycarbonyl)amino]-3-[N₃-benzoyl(thymin-1-yl)]-L-propanol

Chemical Property of 1-O-isobutyryl-2-[(tert-butyloxycarbonyl)amino]-3-[N₃-benzoyl(thymin-1-yl)]-L-propanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-O-isobutyryl-2-[(tert-butyloxycarbonyl)amino]-3-[N₃-benzoyl(thymin-1-yl)]-L-propanol

There total 7 articles about 1-O-isobutyryl-2-[(tert-butyloxycarbonyl)amino]-3-[N₃-benzoyl(thymin-1-yl)]-L-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-Methylpropionic anhydride (97-72-3) + 2-[(tert-butyloxycarbonyl)amino]-3-[N3-benzoyl(thymin-1-yl)]-L-propan-1-ol (179472-13-0) → 1-O-isobutyryl-2-[(tert-butyloxycarbonyl)amino]-3-[N3-benzoyl(thymin-1-yl)]-L-propanol (179472-14-1)

Guidance literature:

With TEA; In pyridine; at 20 ℃; for 12h;

DOI:10.1080/07328319908044847

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 1-O-isobutyryl-2-[(tert-butyloxycarbonyl)amino]-3-[N3-benzoyl(thymin-1-yl)]-L-propanol (179472-14-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 93 percent / Et₃N / tetrahydrofuran; H₂O / 20 °C

2: TEA / tetrahydrofuran / 0.5 h / -20 °C

3: 4.7 g / NaBH₄ / tetrahydrofuran; H₂O / 2 h / 0 °C

4: 86 percent / Ph₃P; DEAD / tetrahydrofuran / 24 h / 20 °C

5: 92 percent / H₂ / Pd/C / methanol / 12 h / 2585.74 Torr

6: 85 percent / TEA / pyridine / 12 h / 20 °C

With sodium tetrahydroborate; TEA; hydrogen; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; water; 1: Esterification / 2: Esterification / 3: Reduction / 4: Alkylation / 5: Hydrogenation / 6: Esterification;

DOI:10.1080/07328319908044847

Reference yield:

BOC-O-benzyl-L-serine (23680-31-1) → 1-O-isobutyryl-2-[(tert-butyloxycarbonyl)amino]-3-[N3-benzoyl(thymin-1-yl)]-L-propanol (179472-14-1)

Guidance literature:

Multi-step reaction with 5 steps

1: TEA / tetrahydrofuran / 0.5 h / -20 °C

2: 4.7 g / NaBH₄ / tetrahydrofuran; H₂O / 2 h / 0 °C

3: 86 percent / Ph₃P; DEAD / tetrahydrofuran / 24 h / 20 °C

4: 92 percent / H₂ / Pd/C / methanol / 12 h / 2585.74 Torr

5: 85 percent / TEA / pyridine / 12 h / 20 °C

With sodium tetrahydroborate; TEA; hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; water; 1: Esterification / 2: Reduction / 3: Alkylation / 4: Hydrogenation / 5: Esterification;

DOI:10.1080/07328319908044847

upstream raw materials:

2-Methylpropionic anhydride

2-[(tert-butyloxycarbonyl)amino]-3-[N₃-benzoyl(thymin-1-yl)]-L-propan-1-ol

di-tert-butyl dicarbonate

BOC-O-benzyl-L-serine

Downstream raw materials:

1-O-isobutyryl-2-[(β-hydroxyacetyl)amino]-3-[N3-benzoyl(thymin-1-yl)]-L-propanol

2-[[β-(4,4'-dimethoxytrityl)-O-acetyl]amino]-3-(thymin-1-yl)-L-propanol

1-O-isobutyryl-2-[[β-(4,4'-dimethoxytrityl)-O-acetyl]amino]-3-[N3-benzoyl(thymin-1-yl)]-L-propanol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 179472-14-1 1-O-isobutyryl-2-[(tert-butyloxycarbonyl)amino]-3-[N₃-benzoyl(thymin-1-yl)]-L-propanol

Send

Send

Metric Ton KG G Pound L ML

Send

Send