S-methyl 1-[(3R,4R)-1-acetyl-4-tosylamidopiperidin-3-yl]pyrrolidine-2-carboxylate

Base Information

Chemical Name:S-methyl 1-[(3R,4R)-1-acetyl-4-tosylamidopiperidin-3-yl]pyrrolidine-2-carboxylate
CAS No.:1579997-47-9
Molecular Formula:C₂₀H₂₉N₃O₅S
Molecular Weight:423.533
Hs Code.:

Synonyms:S-methyl 1-[(3R,4R)-1-acetyl-4-tosylamidopiperidin-3-yl]pyrrolidine-2-carboxylate

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Chemical Property of S-methyl 1-[(3R,4R)-1-acetyl-4-tosylamidopiperidin-3-yl]pyrrolidine-2-carboxylate

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Technology Process of S-methyl 1-[(3R,4R)-1-acetyl-4-tosylamidopiperidin-3-yl]pyrrolidine-2-carboxylate

There total 4 articles about S-methyl 1-[(3R,4R)-1-acetyl-4-tosylamidopiperidin-3-yl]pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1579997-45-7
S-methyl 1-[(3R,4R)-1-benzyl-4-tosylamidopiperidin-3-yl]pyrrolidine-2-carboxylate

: 108-24-7
acetic anhydride

: 1579997-47-9
S-methyl 1-[(3R,4R)-1-acetyl-4-tosylamidopiperidin-3-yl]pyrrolidine-2-carboxylate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In toluene; at 25 ℃; for 12h; under 760.051 Torr;
DOI:10.1021/jo500237j

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1579997-47-9
S-methyl 1-[(3R,4R)-1-acetyl-4-tosylamidopiperidin-3-yl]pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / 1,2-dichloro-ethane / 0.25 h / Inert atmosphere

1.2: 0.5 h / Inert atmosphere; Molecular sieve

2.1: palladium 10% on activated carbon; hydrogen / toluene / 12 h / 25 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; triethylamine; In 1,2-dichloro-ethane; toluene;
DOI:10.1021/jo500237j

Reference yield:

: (S)-pyrrolidine-2-carboxylic acid methyl ester hydrochloride

: 1579997-47-9
S-methyl 1-[(3R,4R)-1-acetyl-4-tosylamidopiperidin-3-yl]pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / 1,2-dichloro-ethane / 0.25 h / Inert atmosphere

1.2: 0.5 h / Inert atmosphere; Molecular sieve

2.1: palladium 10% on activated carbon; hydrogen / toluene / 12 h / 25 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; triethylamine; In 1,2-dichloro-ethane; toluene;
DOI:10.1021/jo500237j