ethyl cis-4-{[1-(5-formylpyridin-2-yl)piperidin-4-yl]oxy}-1-methylcyclohexanecarboxylate

Base Information

Chemical Name:ethyl cis-4-{[1-(5-formylpyridin-2-yl)piperidin-4-yl]oxy}-1-methylcyclohexanecarboxylate
CAS No.:1415573-63-5
Molecular Formula:C₂₁H₃₀N₂O₄
Molecular Weight:374.48
Hs Code.:

Synonyms:ethyl cis-4-{[1-(5-formylpyridin-2-yl)piperidin-4-yl]oxy}-1-methylcyclohexanecarboxylate

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Chemical Property of ethyl cis-4-{[1-(5-formylpyridin-2-yl)piperidin-4-yl]oxy}-1-methylcyclohexanecarboxylate

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Technology Process of ethyl cis-4-{[1-(5-formylpyridin-2-yl)piperidin-4-yl]oxy}-1-methylcyclohexanecarboxylate

There total 11 articles about ethyl cis-4-{[1-(5-formylpyridin-2-yl)piperidin-4-yl]oxy}-1-methylcyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.4%

: 677728-92-6
2-fluoro-5-formylpyridine

: 1415573-57-7
ethyl 1-methyl-4-(piperidin-4-yloxy)cyclohexanecarboxylate

: 1415573-63-5
ethyl cis-4-{[1-(5-formylpyridin-2-yl)piperidin-4-yl]oxy}-1-methylcyclohexanecarboxylate

Guidance literature:: With sodium hydrogencarbonate; In dimethyl sulfoxide; at 110 ℃; for 4h; Inert atmosphere;

Reference yield:

: 1489-97-0
ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate

: 1415573-63-5
ethyl cis-4-{[1-(5-formylpyridin-2-yl)piperidin-4-yl]oxy}-1-methylcyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

1.2: 2 h / -78 °C

2.1: hydrogenchloride / water; acetone / 48 h / 20 °C

3.1: sodium tetrahydroborate; methanol / 1.5 h / 0 °C

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 48 h / 55 °C / Inert atmosphere

5.1: ChiraPak AY-H / Resolution of racemate

6.1: hydrogen; acetic acid / Rh/C / 80 °C / 60006 Torr

7.1: sodium hydrogencarbonate / dimethyl sulfoxide / 4 h / 110 °C / Inert atmosphere

With hydrogenchloride; methanol; sodium tetrahydroborate; di-isopropyl azodicarboxylate; hydrogen; sodium hydrogencarbonate; acetic acid; triphenylphosphine; lithium diisopropyl amide; Rh/C; In tetrahydrofuran; water; dimethyl sulfoxide; acetone;

Reference yield:

: 147905-77-9
ethyl 1-methyl-4-oxo-1-cyclohexanecarboxylate

: 1415573-63-5
ethyl cis-4-{[1-(5-formylpyridin-2-yl)piperidin-4-yl]oxy}-1-methylcyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate; methanol / 1.5 h / 0 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 48 h / 55 °C / Inert atmosphere

3: ChiraPak AY-H / Resolution of racemate

4: hydrogen; acetic acid / Rh/C / 80 °C / 60006 Torr

5: sodium hydrogencarbonate / dimethyl sulfoxide / 4 h / 110 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; di-isopropyl azodicarboxylate; hydrogen; sodium hydrogencarbonate; acetic acid; triphenylphosphine; Rh/C; In tetrahydrofuran; dimethyl sulfoxide;