(R)-1-(1-(1-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)-1H-1,2,3-triazol-4-yl)-2,5,8,11-tetraoxatridecan-13-yl)-2,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methanoisoindole

Base Information

Chemical Name:(R)-1-(1-(1-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)-1H-1,2,3-triazol-4-yl)-2,5,8,11-tetraoxatridecan-13-yl)-2,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methanoisoindole
CAS No.:1309042-01-0
Molecular Formula:C₃₅H₄₅FN₆O₉
Molecular Weight:712.776
Hs Code.:

(R)-1-(1-(1-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)-1H-1,2,3-triazol-4-yl)-2,5,8,11-tetraoxatridecan-13-yl)-2,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methanoisoindole

Synonyms:(R)-1-(1-(1-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)-1H-1,2,3-triazol-4-yl)-2,5,8,11-tetraoxatridecan-13-yl)-2,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methanoisoindole

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Chemical Property of (R)-1-(1-(1-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)-1H-1,2,3-triazol-4-yl)-2,5,8,11-tetraoxatridecan-13-yl)-2,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methanoisoindole

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Technology Process of (R)-1-(1-(1-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)-1H-1,2,3-triazol-4-yl)-2,5,8,11-tetraoxatridecan-13-yl)-2,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methanoisoindole

There total 5 articles about (R)-1-(1-(1-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)-1H-1,2,3-triazol-4-yl)-2,5,8,11-tetraoxatridecan-13-yl)-2,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methanoisoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1308299-12-8
N-(3,6,9,12-tetraoxapentadec-14-ynyl)-2,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-isoindol

: 168828-84-0
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one

: 1309042-01-0
(R)-1-(1-(1-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)-1H-1,2,3-triazol-4-yl)-2,5,8,11-tetraoxatridecan-13-yl)-2,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methanoisoindole

Guidance literature:: With copper(l) iodide; triethylamine; In acetonitrile; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.2174/157340611794072670

Reference yield:

: 875770-32-4
toluene-4-sulfonic acid 2-{2-[2-(2-ethynyloxyethoxy)-ethoxy]-ethoxy}-ethyl ester

: 1309042-01-0
(R)-1-(1-(1-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)-1H-1,2,3-triazol-4-yl)-2,5,8,11-tetraoxatridecan-13-yl)-2,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methanoisoindole

Guidance literature:: Multi-step reaction with 3 steps

1: potassium bromide / N,N-dimethyl-formamide / 100 °C

2: potassium carbonate / acetonitrile / 2 h / Reflux

3: copper(l) iodide; triethylamine / acetonitrile / 2 h / 20 °C / Inert atmosphere

With copper(l) iodide; potassium carbonate; triethylamine; potassium bromide; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.2174/157340611794072670

Reference yield:

: 87450-10-0
3,6,9,12-tetraoxapentadec-14-yn-1-ol

: 1309042-01-0
(R)-1-(1-(1-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)-1H-1,2,3-triazol-4-yl)-2,5,8,11-tetraoxatridecan-13-yl)-2,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methanoisoindole

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 0 - 20 °C

2: potassium bromide / N,N-dimethyl-formamide / 100 °C

3: potassium carbonate / acetonitrile / 2 h / Reflux

4: copper(l) iodide; triethylamine / acetonitrile / 2 h / 20 °C / Inert atmosphere

With pyridine; copper(l) iodide; potassium carbonate; triethylamine; potassium bromide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.2174/157340611794072670