1-[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazol-3-yl]ethanone

Base Information

Chemical Name:1-[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazol-3-yl]ethanone
CAS No.:913572-17-5
Molecular Formula:C₂₀H₁₉ClN₂O₂
Molecular Weight:354.836
Hs Code.:

Synonyms:1-[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazol-3-yl]ethanone

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Chemical Property of 1-[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazol-3-yl]ethanone

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Technology Process of 1-[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazol-3-yl]ethanone

There total 5 articles about 1-[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazol-3-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 913572-15-3
1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-N,5-dimethyl-N-(methyloxy)-1H-pyrazole-3-carboxamide

: 75-16-1
methylmagnesium bromide

: 913572-17-5
1-[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazol-3-yl]ethanone

Guidance literature:: 1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-N,5-dimethyl-N-(methyloxy)-1H-pyrazole-3-carboxamide; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 20 ℃; for 0.5h;

With hydrogenchloride; In tetrahydrofuran; diethyl ether;

Reference yield:

: 851205-62-4
1-(5-chloro-2-hydroxybenzyl)-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

: 913572-17-5
1-[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazol-3-yl]ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 18 h / Heating / reflux

2: sodium hydroxide; ethanol; water / 0.5 h / Heating / reflux

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 16 h / 20 °C

4: tetrahydrofuran; diethyl ether / 0.5 h / 20 °C

With sodium hydroxide; ethanol; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; acetone;

Reference yield:

: 851204-79-0
1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazole-3-carboxylic acid

: 913572-17-5
1-[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazol-3-yl]ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 16 h / 20 °C

2: tetrahydrofuran; diethyl ether / 0.5 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;