2-bromo-1-[2-bromo-6-(trifluoromethyl)phenyl]-1H-pyrrole-5-carboxylic acid

Base Information

Chemical Name:2-bromo-1-[2-bromo-6-(trifluoromethyl)phenyl]-1H-pyrrole-5-carboxylic acid
CAS No.:1376707-86-6
Molecular Formula:C₁₂H₆Br₂F₃NO₂
Molecular Weight:412.988
Hs Code.:

Synonyms:2-bromo-1-[2-bromo-6-(trifluoromethyl)phenyl]-1H-pyrrole-5-carboxylic acid

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Chemical Property of 2-bromo-1-[2-bromo-6-(trifluoromethyl)phenyl]-1H-pyrrole-5-carboxylic acid

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Technology Process of 2-bromo-1-[2-bromo-6-(trifluoromethyl)phenyl]-1H-pyrrole-5-carboxylic acid

There total 4 articles about 2-bromo-1-[2-bromo-6-(trifluoromethyl)phenyl]-1H-pyrrole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-38-9,18923-20-1
carbon dioxide

: 1376707-80-0
2,5-dibromo-1-[2-bromo-6-(trifluoromethyl)phenyl]-1H-pyrrole

: 1376707-86-6
2-bromo-1-[2-bromo-6-(trifluoromethyl)phenyl]-1H-pyrrole-5-carboxylic acid

: 1376707-85-5
2,5-dibromo-1-[2-carboxy-6-(trifluoromethyl)phenyl]-1H-pyrrole

Guidance literature:: 2,5-dibromo-1-[2-bromo-6-(trifluoromethyl)phenyl]-1H-pyrrole; With n-butyllithium; In tetrahydrofuran; hexane; at -75 ℃; for 0.5h; Inert atmosphere;

carbon dioxide; In tetrahydrofuran; hexane; at -190 - 20 ℃; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; hexane; water; ethyl acetate; at 20 ℃; regioselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2012.03.070

Reference yield:

: 1376707-79-7
2-bromo-1-[2-bromo-6-(trifluoromethyl)phenyl]-1H-pyrrole

: 1376707-86-6
2-bromo-1-[2-bromo-6-(trifluoromethyl)phenyl]-1H-pyrrole-5-carboxylic acid

: 1376707-85-5
2,5-dibromo-1-[2-carboxy-6-(trifluoromethyl)phenyl]-1H-pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.33 h / 0 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -75 °C / Inert atmosphere

2.2: -190 - 20 °C / Inert atmosphere

2.3: 20 °C / Inert atmosphere

With N-Bromosuccinimide; n-butyllithium; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.03.070

Reference yield:

: 89108-30-5
1-<(2-trifluoromethyl)phenyl>pyrrole

: 1376707-86-6
2-bromo-1-[2-bromo-6-(trifluoromethyl)phenyl]-1H-pyrrole-5-carboxylic acid

: 1376707-85-5
2,5-dibromo-1-[2-carboxy-6-(trifluoromethyl)phenyl]-1H-pyrrole

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; potassium tert-butylate / diethyl ether; hexane / 1 h / -75 - -40 °C / Inert atmosphere

1.2: -75 - 25 °C / Inert atmosphere

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.33 h / 0 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -75 °C / Inert atmosphere

3.2: -190 - 20 °C / Inert atmosphere

3.3: 20 °C / Inert atmosphere

With N-Bromosuccinimide; n-butyllithium; potassium tert-butylate; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.03.070