triisopropylsilyl 2-bromo-5-chloro-4-((triisopropylsilyloxy)methyl)benzoate

Base Information

Chemical Name:triisopropylsilyl 2-bromo-5-chloro-4-((triisopropylsilyloxy)methyl)benzoate
CAS No.:1352713-57-5
Molecular Formula:C₂₆H₄₆BrClO₃Si₂
Molecular Weight:578.177
Hs Code.:

Synonyms:triisopropylsilyl 2-bromo-5-chloro-4-((triisopropylsilyloxy)methyl)benzoate

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Chemical Property of triisopropylsilyl 2-bromo-5-chloro-4-((triisopropylsilyloxy)methyl)benzoate

Chemical Property:

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Technology Process of triisopropylsilyl 2-bromo-5-chloro-4-((triisopropylsilyloxy)methyl)benzoate

There total 7 articles about triisopropylsilyl 2-bromo-5-chloro-4-((triisopropylsilyloxy)methyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 13154-24-0
triisopropylsilyl chloride

: 1313513-39-1
2-bromo-5-chloro-4-(hydroxymethyl)benzoic acid

: 1352713-57-5
triisopropylsilyl 2-bromo-5-chloro-4-((triisopropylsilyloxy)methyl)benzoate

Guidance literature:: With 1H-imidazole; dmap; In N,N-dimethyl-formamide; at 20 ℃; for 15h; Inert atmosphere;

Reference yield:

: 474330-54-6
5-amino-2-bromo-4-methylbenzoic acid methyl ester

: 1352713-57-5
triisopropylsilyl 2-bromo-5-chloro-4-((triisopropylsilyloxy)methyl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; sodium nitrite / 1,4-dioxane; water / 2 h / 0 °C

1.2: 0.5 h / 0 °C

2.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 15 h / 85 °C / Inert atmosphere

3.1: N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 15 h / 20 °C

4.2: 0 °C

5.1: 1H-imidazole / dmap / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

With 1H-imidazole; hydrogenchloride; N-Bromosuccinimide; lithium hydroxide monohydrate; 2,2'-azobis(isobutyronitrile); water; sodium nitrite; dmap; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; water; N,N-dimethyl-formamide; 1.2: Sandmeyer Reaction;

Reference yield:

: 2458-12-0
3-amino-p-toluic acid

: 1352713-57-5
triisopropylsilyl 2-bromo-5-chloro-4-((triisopropylsilyloxy)methyl)benzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

2.1: thionyl chloride / 15 h / 0 °C / Reflux; Inert atmosphere

3.1: hydrogenchloride; sodium nitrite / 1,4-dioxane; water / 2 h / 0 °C

3.2: 0.5 h / 0 °C

4.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 15 h / 85 °C / Inert atmosphere

5.1: N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

6.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 15 h / 20 °C

6.2: 0 °C

7.1: 1H-imidazole / dmap / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

With 1H-imidazole; hydrogenchloride; N-Bromosuccinimide; thionyl chloride; lithium hydroxide monohydrate; 2,2'-azobis(isobutyronitrile); water; sodium nitrite; dmap; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; water; N,N-dimethyl-formamide; 3.2: Sandmeyer Reaction;