N-(3-((3S)-5-amino-3-(fluoromethyl)-6,6-dimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5-fluoro-3-methoxy-1,7-naphthyridin-8-amine

Base Information

Chemical Name:N-(3-((3S)-5-amino-3-(fluoromethyl)-6,6-dimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5-fluoro-3-methoxy-1,7-naphthyridin-8-amine
CAS No.:1600508-19-7
Molecular Formula:C₂₂H₂₂F₃N₅O₃S
Molecular Weight:493.51
Hs Code.:

N-(3-((3S)-5-amino-3-(fluoromethyl)-6,6-dimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5-fluoro-3-methoxy-1,7-naphthyridin-8-amine

Synonyms:N-(3-((3S)-5-amino-3-(fluoromethyl)-6,6-dimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5-fluoro-3-methoxy-1,7-naphthyridin-8-amine

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Chemical Property of N-(3-((3S)-5-amino-3-(fluoromethyl)-6,6-dimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5-fluoro-3-methoxy-1,7-naphthyridin-8-amine

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Technology Process of N-(3-((3S)-5-amino-3-(fluoromethyl)-6,6-dimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5-fluoro-3-methoxy-1,7-naphthyridin-8-amine

There total 5 articles about N-(3-((3S)-5-amino-3-(fluoromethyl)-6,6-dimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5-fluoro-3-methoxy-1,7-naphthyridin-8-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1600511-84-9
8-chloro-5-fluoro-3-methoxy-1,7-naphthyridine

: 1600511-23-6
(S)-5-amino-3-(5-amino-2-fluorophenyl)-3-(fluoromethyl)-6,6-dimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

: 1600508-19-7
N-(3-((3S)-5-amino-3-(fluoromethyl)-6,6-dimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5-fluoro-3-methoxy-1,7-naphthyridin-8-amine

Guidance literature:: With sulfuric acid; In isopropyl alcohol;

Reference yield:

: 1600511-73-6
5-chloro-3-((trimethylsilyl)ethynyl)picolinonitrile

: 1600508-19-7
N-(3-((3S)-5-amino-3-(fluoromethyl)-6,6-dimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5-fluoro-3-methoxy-1,7-naphthyridin-8-amine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium methylate / methanol

2: sodium carbonate; toluene-4-sulfonic acid; dihydrogen peroxide / water; ethyl acetate; [⁽²⁾H₆]acetone; benzene

4: sulfuric acid / isopropyl alcohol

With sulfuric acid; dihydrogen peroxide; sodium methylate; sodium carbonate; toluene-4-sulfonic acid; In methanol; [⁽²⁾H₆]acetone; water; ethyl acetate; isopropyl alcohol; benzene;

Reference yield:

: 760207-83-8
3-bromo-5-chloropyridine-2-carbonitrile

: 1600508-19-7
N-(3-((3S)-5-amino-3-(fluoromethyl)-6,6-dimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-5-fluoro-3-methoxy-1,7-naphthyridin-8-amine

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / N,N-dimethyl-formamide; ethyl acetate; hexane

2: sodium methylate / methanol

3: sodium carbonate; toluene-4-sulfonic acid; dihydrogen peroxide / water; ethyl acetate; [⁽²⁾H₆]acetone; benzene

5: sulfuric acid / isopropyl alcohol

With sulfuric acid; dihydrogen peroxide; sodium methylate; sodium carbonate; toluene-4-sulfonic acid; triethylamine; In methanol; [⁽²⁾H₆]acetone; hexane; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; benzene;