N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yI]-2-{4-[(2,2,2-trifluoroethyl)sulfonyl]phenyl}acetamide

Base Information

Chemical Name:N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yI]-2-{4-[(2,2,2-trifluoroethyl)sulfonyl]phenyl}acetamide
CAS No.:1363178-92-0
Molecular Formula:C₂₆H₁₉F₃N₂O₄S₂
Molecular Weight:544.575
Hs Code.:

Synonyms:N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yI]-2-{4-[(2,2,2-trifluoroethyl)sulfonyl]phenyl}acetamide

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Chemical Property of N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yI]-2-{4-[(2,2,2-trifluoroethyl)sulfonyl]phenyl}acetamide

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Technology Process of N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yI]-2-{4-[(2,2,2-trifluoroethyl)sulfonyl]phenyl}acetamide

There total 8 articles about N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yI]-2-{4-[(2,2,2-trifluoroethyl)sulfonyl]phenyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1153070-21-3
2-(4-((2,2,2-trifluoroethyl)sulfonyl)phenyl)acetic acid

: 17279-56-0
(2-amino-4-phenyl-1,3-thiazol-5-yl)(phenyl)methanone

: 1363178-92-0
N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yI]-2-{4-[(2,2,2-trifluoroethyl)sulfonyl]phenyl}acetamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

: 91361-92-1
(4-mercapto-phenyl)-acetic acid methyl ester

: 1363178-92-0
N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yI]-2-{4-[(2,2,2-trifluoroethyl)sulfonyl]phenyl}acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

3: hydrogenchloride / acetic acid / 1.5 h / 105 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C / Inert atmosphere

With hydrogenchloride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 120-46-7,61346-73-4
1,3-diphenylpropanedione

: 1363178-92-0
N-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yI]-2-{4-[(2,2,2-trifluoroethyl)sulfonyl]phenyl}acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: bromine / ethyl acetate / 0 °C

1.2: 0.25 h / 85 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C / Inert atmosphere

With bromine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; ethyl acetate;