ethyl 5-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)pentanoate

Base Information

• Chemical Name: ethyl 5-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)pentanoate
• CAS No.: 1214998-21-6
• Molecular Formula: C₂₄H₂₅N₃O₄
• Molecular Weight: 419.48
• Mol file: 1214998-21-6.mol

Synonyms:ethyl 5-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)pentanoate

Chemical Property of ethyl 5-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)pentanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of ethyl 5-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)pentanoate

There total 1 articles about ethyl 5-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-[(3-acetylenephenyl)amino]-7-methoxyquinazolin-6-ol (905306-05-0) + ethyl 5-bromovalerate (14660-52-7) → ethyl 5-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)pentanoate (1214998-21-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 0.5h;

DOI:10.1021/jm901453q

Reference yield: 40.0%

ethyl 5-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)pentanoate (1214998-21-6) → 5-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yloxy)-N-hydroxypentanamide

Guidance literature:

With hydroxylamine; In methanol; at 0 - 25 ℃;

DOI:10.1021/jm901453q

upstream raw materials:

4-[(3-acetylenephenyl)amino]-7-methoxyquinazolin-6-ol

ethyl 5-bromovalerate