N-methyl-4-[4-[(3S)-3-methylmorpholin-4-yl]-6-(methylsulfonylmethyl)pyrimidin-2-yl]aniline

Base Information

Chemical Name:N-methyl-4-[4-[(3S)-3-methylmorpholin-4-yl]-6-(methylsulfonylmethyl)pyrimidin-2-yl]aniline
CAS No.:1009627-18-2
Molecular Formula:C₁₈H₂₄N₄O₃S
Molecular Weight:376.48
Hs Code.:

Synonyms:N-methyl-4-[4-[(3S)-3-methylmorpholin-4-yl]-6-(methylsulfonylmethyl)pyrimidin-2-yl]aniline

Suppliers and Price of N-methyl-4-[4-[(3S)-3-methylmorpholin-4-yl]-6-(methylsulfonylmethyl)pyrimidin-2-yl]aniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-methyl-4-[4-[(3S)-3-methylmorpholin-4-yl]-6-(methylsulfonylmethyl)pyrimidin-2-yl]aniline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-methyl-4-[4-[(3S)-3-methylmorpholin-4-yl]-6-(methylsulfonylmethyl)pyrimidin-2-yl]aniline

There total 7 articles about N-methyl-4-[4-[(3S)-3-methylmorpholin-4-yl]-6-(methylsulfonylmethyl)pyrimidin-2-yl]aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 845870-55-5
N-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine

: 1009627-11-5
2-chloro-4-[(3S)-3-methylmorpholin-4-yl]-6-(methylsulfonylmethyl)pyrimidine

: 1009627-18-2
N-methyl-4-[4-[(3S)-3-methylmorpholin-4-yl]-6-(methylsulfonylmethyl)pyrimidin-2-yl]aniline

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; at 90 ℃; for 3h;

Reference yield:

: 350595-57-2
(S)-3-methylmorpholine

: 1009627-18-2
N-methyl-4-[4-[(3S)-3-methylmorpholin-4-yl]-6-(methylsulfonylmethyl)pyrimidin-2-yl]aniline

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 1 h / 20 °C

2: lithium borohydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0.75 h / 0 - 20 °C / Inert atmosphere

4: sodium iodide / 20 h / 50 °C

5: acetonitrile / 24 h / 85 °C

6: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; N,N-dimethyl-formamide; ethanol; 1,2-dimethoxyethane / 5 h / 80 - 95 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; lithium borohydride; sodium carbonate; triethylamine; sodium iodide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm501778s

Reference yield:

: 1009628-23-2
(S)-(2-chloro-6-(3-methylmorpholino)pyrimidin-4-yl)methyl methanesulfonate

: 1009627-18-2
N-methyl-4-[4-[(3S)-3-methylmorpholin-4-yl]-6-(methylsulfonylmethyl)pyrimidin-2-yl]aniline

Guidance literature:: Multi-step reaction with 3 steps

1: sodium iodide / 20 h / 50 °C

2: acetonitrile / 24 h / 85 °C

3: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; N,N-dimethyl-formamide; ethanol; 1,2-dimethoxyethane / 5 h / 80 - 95 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; sodium iodide; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm501778s