4-hydroxy-2-oxo-6-((R)-phenyl((R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyloxy) methyl)-1,2-dihydropyridine-3-carboxylic acid

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Chemical Name:4-hydroxy-2-oxo-6-((R)-phenyl((R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyloxy) methyl)-1,2-dihydropyridine-3-carboxylic acid
CAS No.:1300040-38-3
Molecular Formula:C₂₃H₁₈F₃NO₇
Molecular Weight:477.394
Hs Code.:

Synonyms:4-hydroxy-2-oxo-6-((R)-phenyl((R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyloxy) methyl)-1,2-dihydropyridine-3-carboxylic acid

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Chemical Property of 4-hydroxy-2-oxo-6-((R)-phenyl((R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyloxy) methyl)-1,2-dihydropyridine-3-carboxylic acid

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Technology Process of 4-hydroxy-2-oxo-6-((R)-phenyl((R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyloxy) methyl)-1,2-dihydropyridine-3-carboxylic acid

There total 2 articles about 4-hydroxy-2-oxo-6-((R)-phenyl((R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyloxy) methyl)-1,2-dihydropyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1300040-42-9
(R)-4-hydroxy-6-(hydroxy(phenyl)methyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

: 20445-31-2
R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid

: 1300040-38-3
4-hydroxy-2-oxo-6-((R)-phenyl((R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyloxy) methyl)-1,2-dihydropyridine-3-carboxylic acid

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 6h; regioselective reaction; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.02.039

Reference yield:

: 1228555-64-3
C₁₃H₉NO₅

: 1300040-38-3
4-hydroxy-2-oxo-6-((R)-phenyl((R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyloxy) methyl)-1,2-dihydropyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: (+)-B-chlorodiisopinocampheylborane / tetrahydrofuran / 12 h / -40 - -10 °C / Inert atmosphere

1.2: Inert atmosphere; Cooling with ice

2.1: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran; dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere

With dmap; dicyclohexyl-carbodiimide; (+)-B-chlorodiisopinocampheylborane; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2011.02.039