4-[4-(6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]cyclohexanecarboxylic acid

Base Information

Chemical Name:4-[4-(6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]cyclohexanecarboxylic acid
CAS No.:1067677-37-5
Molecular Formula:C₂₀H₂₇N₃O₃
Molecular Weight:357.453
Hs Code.:

Synonyms:4-[4-(6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]cyclohexanecarboxylic acid

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Chemical Property of 4-[4-(6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]cyclohexanecarboxylic acid

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Technology Process of 4-[4-(6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]cyclohexanecarboxylic acid

There total 6 articles about 4-[4-(6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1067677-36-4
ethyl 4-[4-(6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]cyclohexanecarboxylate

: 1067677-37-5
4-[4-(6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]cyclohexanecarboxylic acid

Guidance literature:: ethyl 4-[4-(6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]cyclohexanecarboxylate; With sodium hydroxide; water; In tetrahydrofuran; methanol; at 20 ℃; for 1h;

With hydrogenchloride; In water; pH=~ 3;

Reference yield:

: 446-34-4
2-fluoro-4-methyl-1-nitrobenzene

: 1067677-37-5
4-[4-(6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 - 90 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C

3.1: acetonitrile / 24.16 h / 20 - 40 °C

4.1: hydrogenchloride / 1,4-dioxane; methanol; dichloromethane / 20 h / 20 °C

5.1: sodium carbonate / dichloromethane; water

6.1: (polystyrylmethyl)trimethylammonium cyanoborohydride; acetic acid / dichloromethane / 0.33 h / 110 °C / microwave irradiation

7.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 20 °C

7.2: pH ~ 3

With hydrogenchloride; sodium hydroxide; (polystyrylmethyl)trimethylammonium cyanoborohydride; water; hydrogen; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 950772-97-1
1,1-dimethylethyl 4-[(5-methyl-2-nitrophenyl)amino]-1-piperidinecarboxylate

: 1067677-37-5
4-[4-(6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C

2.1: acetonitrile / 24.16 h / 20 - 40 °C

3.1: hydrogenchloride / 1,4-dioxane; methanol; dichloromethane / 20 h / 20 °C

4.1: sodium carbonate / dichloromethane; water

5.1: (polystyrylmethyl)trimethylammonium cyanoborohydride; acetic acid / dichloromethane / 0.33 h / 110 °C / microwave irradiation

6.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 20 °C

6.2: pH ~ 3

With hydrogenchloride; sodium hydroxide; (polystyrylmethyl)trimethylammonium cyanoborohydride; water; hydrogen; sodium carbonate; acetic acid; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetonitrile;