ethyl 4-[4-(6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]cyclohexanecarboxylate

Base Information

Chemical Name:ethyl 4-[4-(6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]cyclohexanecarboxylate
CAS No.:1067677-36-4
Molecular Formula:C₂₂H₃₁N₃O₃
Molecular Weight:385.506
Hs Code.:

Synonyms:ethyl 4-[4-(6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]cyclohexanecarboxylate

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Chemical Property of ethyl 4-[4-(6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]cyclohexanecarboxylate

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Technology Process of ethyl 4-[4-(6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]cyclohexanecarboxylate

There total 5 articles about ethyl 4-[4-(6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17159-79-4
ethyl 4-oxocyclohexane-1-carboxylate

: 85076-01-3
(6-methyl-1-piperidin-4-yl)-1,3-dihydrobenzimidazol-2-one

: 1067677-36-4
ethyl 4-[4-(6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]cyclohexanecarboxylate

Guidance literature:: ethyl 4-oxocyclohexane-1-carboxylate; (6-methyl-1-piperidin-4-yl)-1,3-dihydrobenzimidazol-2-one; With (polystyrylmethyl)trimethylammonium cyanoborohydride; acetic acid; In dichloromethane; at 110 ℃; for 0.333333h; Polystyrene microwave irradiation;

With ammonia; In methanol;

Reference yield:

: 446-34-4
2-fluoro-4-methyl-1-nitrobenzene

: 1067677-36-4
ethyl 4-[4-(6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 - 90 °C

2: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C

3: acetonitrile / 24.16 h / 20 - 40 °C

4: hydrogenchloride / 1,4-dioxane; methanol; dichloromethane / 20 h / 20 °C

5: sodium carbonate / dichloromethane; water

6: (polystyrylmethyl)trimethylammonium cyanoborohydride; acetic acid / dichloromethane / 0.33 h / 110 °C / microwave irradiation

With hydrogenchloride; (polystyrylmethyl)trimethylammonium cyanoborohydride; hydrogen; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 950772-97-1
1,1-dimethylethyl 4-[(5-methyl-2-nitrophenyl)amino]-1-piperidinecarboxylate

: 1067677-36-4
ethyl 4-[4-(6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C

2: acetonitrile / 24.16 h / 20 - 40 °C

3: hydrogenchloride / 1,4-dioxane; methanol; dichloromethane / 20 h / 20 °C

4: sodium carbonate / dichloromethane; water

5: (polystyrylmethyl)trimethylammonium cyanoborohydride; acetic acid / dichloromethane / 0.33 h / 110 °C / microwave irradiation

With hydrogenchloride; (polystyrylmethyl)trimethylammonium cyanoborohydride; hydrogen; sodium carbonate; acetic acid; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetonitrile;