(E)-(4R,5S)-5-[(E)-(4R,5S)-5-((R)-3-Hydroxy-butyryloxy)-4-(4-methoxy-benzyloxy)-hex-2-enoyloxy]-4-(4-methoxy-benzyloxy)-hex-2-enoic acid

Base Information

Chemical Name:(E)-(4R,5S)-5-[(E)-(4R,5S)-5-((R)-3-Hydroxy-butyryloxy)-4-(4-methoxy-benzyloxy)-hex-2-enoyloxy]-4-(4-methoxy-benzyloxy)-hex-2-enoic acid
CAS No.:503026-51-5
Molecular Formula:C₃₂H₄₀O₁₁
Molecular Weight:600.663
Hs Code.:

Synonyms:(E)-(4R,5S)-5-[(E)-(4R,5S)-5-((R)-3-Hydroxy-butyryloxy)-4-(4-methoxy-benzyloxy)-hex-2-enoyloxy]-4-(4-methoxy-benzyloxy)-hex-2-enoic acid

Suppliers and Price of (E)-(4R,5S)-5-[(E)-(4R,5S)-5-((R)-3-Hydroxy-butyryloxy)-4-(4-methoxy-benzyloxy)-hex-2-enoyloxy]-4-(4-methoxy-benzyloxy)-hex-2-enoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-(4R,5S)-5-[(E)-(4R,5S)-5-((R)-3-Hydroxy-butyryloxy)-4-(4-methoxy-benzyloxy)-hex-2-enoyloxy]-4-(4-methoxy-benzyloxy)-hex-2-enoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-(4R,5S)-5-[(E)-(4R,5S)-5-((R)-3-Hydroxy-butyryloxy)-4-(4-methoxy-benzyloxy)-hex-2-enoyloxy]-4-(4-methoxy-benzyloxy)-hex-2-enoic acid

There total 10 articles about (E)-(4R,5S)-5-[(E)-(4R,5S)-5-((R)-3-Hydroxy-butyryloxy)-4-(4-methoxy-benzyloxy)-hex-2-enoyloxy]-4-(4-methoxy-benzyloxy)-hex-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 503026-50-4
(E)-(4R,5S)-5-[(E)-(4R,5S)-5-((R)-3-Hydroxy-butyryloxy)-4-(4-methoxy-benzyloxy)-hex-2-enoyloxy]-4-(4-methoxy-benzyloxy)-hex-2-enoic acid 2-(toluene-4-sulfonyl)-ethyl ester

: 503026-51-5
(E)-(4R,5S)-5-[(E)-(4R,5S)-5-((R)-3-Hydroxy-butyryloxy)-4-(4-methoxy-benzyloxy)-hex-2-enoyloxy]-4-(4-methoxy-benzyloxy)-hex-2-enoic acid

Guidance literature:: With 2,6-dichloro-benzonitrile; In benzene; at 20 ℃; for 8h;
DOI:10.1016/S0040-4039(02)02284-0

Reference yield:

: 2746-25-0
p-Methoxybenzyl bromide

: 503026-51-5
(E)-(4R,5S)-5-[(E)-(4R,5S)-5-((R)-3-Hydroxy-butyryloxy)-4-(4-methoxy-benzyloxy)-hex-2-enoyloxy]-4-(4-methoxy-benzyloxy)-hex-2-enoic acid

Guidance literature:: Multi-step reaction with 10 steps

1: 95 percent / tetrahydrofuran / 4 h / 0 - 20 °C

2: 75 percent / AcOH; water; HCl / 14 h / 20 °C

3: NaIO₄ / methanol; H₂O / 2 h / 20 °C

4: 1 h / 110 °C

5: 80 percent / HCl / dioxane; H₂O / 12 h / 20 °C

6: 83 percent / 2,4,6-trichlorobenzoyl chloride; Et₃N; DMAP / tetrahydrofuran; toluene / 12 h / 20 °C

7: 80 percent / DBN / benzene / 8 h / 20 °C

8: 84 percent / 2,4,6-trichlorobenzoyl chloride; Et₃N; DMAP / tetrahydrofuran; toluene / 12 h / 20 °C

9: 81 percent / TMSCl; NaI / acetonitrile / 6 h / -20 °C

10: 80 percent / DBN / benzene / 8 h / 20 °C

With hydrogenchloride; dmap; sodium periodate; chloro-trimethyl-silane; 2,6-dichloro-benzonitrile; 2,4,6-trichlorobenzoyl chloride; water; acetic acid; triethylamine; sodium iodide; In tetrahydrofuran; 1,4-dioxane; methanol; water; toluene; acetonitrile; benzene;
DOI:10.1016/S0040-4039(02)02284-0

Reference yield:

: Formic acid (1S,2S)-2-(4-methoxy-benzyloxy)-1-methyl-3-oxo-propyl ester

: 503026-51-5
(E)-(4R,5S)-5-[(E)-(4R,5S)-5-((R)-3-Hydroxy-butyryloxy)-4-(4-methoxy-benzyloxy)-hex-2-enoyloxy]-4-(4-methoxy-benzyloxy)-hex-2-enoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 1 h / 110 °C

2: 80 percent / HCl / dioxane; H₂O / 12 h / 20 °C

3: 83 percent / 2,4,6-trichlorobenzoyl chloride; Et₃N; DMAP / tetrahydrofuran; toluene / 12 h / 20 °C

4: 80 percent / DBN / benzene / 8 h / 20 °C

5: 84 percent / 2,4,6-trichlorobenzoyl chloride; Et₃N; DMAP / tetrahydrofuran; toluene / 12 h / 20 °C

6: 81 percent / TMSCl; NaI / acetonitrile / 6 h / -20 °C

7: 80 percent / DBN / benzene / 8 h / 20 °C

With hydrogenchloride; dmap; chloro-trimethyl-silane; 2,6-dichloro-benzonitrile; 2,4,6-trichlorobenzoyl chloride; triethylamine; sodium iodide; In tetrahydrofuran; 1,4-dioxane; water; toluene; acetonitrile; benzene;
DOI:10.1016/S0040-4039(02)02284-0