1-[4-(2-Dimethylamino-ethoxy)-phenyl]-2-phenyl-1-[2-(tetrahydro-pyran-2-yloxy)-phenyl]-butan-1-ol

Base Information

• Chemical Name: 1-[4-(2-Dimethylamino-ethoxy)-phenyl]-2-phenyl-1-[2-(tetrahydro-pyran-2-yloxy)-phenyl]-butan-1-ol
• CAS No.: 97150-94-2
• Molecular Formula: C₃₁H₃₉NO₄
• Molecular Weight: 489.655
• Mol file: 97150-94-2.mol

Synonyms:1-[4-(2-Dimethylamino-ethoxy)-phenyl]-2-phenyl-1-[2-(tetrahydro-pyran-2-yloxy)-phenyl]-butan-1-ol

Chemical Property of 1-[4-(2-Dimethylamino-ethoxy)-phenyl]-2-phenyl-1-[2-(tetrahydro-pyran-2-yloxy)-phenyl]-butan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[4-(2-Dimethylamino-ethoxy)-phenyl]-2-phenyl-1-[2-(tetrahydro-pyran-2-yloxy)-phenyl]-butan-1-ol

There total 3 articles about 1-[4-(2-Dimethylamino-ethoxy)-phenyl]-2-phenyl-1-[2-(tetrahydro-pyran-2-yloxy)-phenyl]-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → 1-[4-(2-Dimethylamino-ethoxy)-phenyl]-2-phenyl-1-[2-(tetrahydro-pyran-2-yloxy)-phenyl]-butan-1-ol (97150-94-2)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-p-sulfonic acid / 1 h / Ambient temperature

2: 1.) n-butyllithium / 1.) hexane, THF, -78 deg C, 30 min, 2.) hexane, THF, RT, 10 h

With n-butyllithium; toluene-4-sulfonic acid;

DOI:10.1021/jm00148a020

Reference yield:

2-hydroxybromobenzene (95-56-7) → 1-[4-(2-Dimethylamino-ethoxy)-phenyl]-2-phenyl-1-[2-(tetrahydro-pyran-2-yloxy)-phenyl]-butan-1-ol (97150-94-2)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-p-sulfonic acid / 1 h / Ambient temperature

2: 1.) n-butyllithium / 1.) hexane, THF, -78 deg C, 30 min, 2.) hexane, THF, RT, 10 h

With n-butyllithium; toluene-4-sulfonic acid;

DOI:10.1021/jm00148a020

Reference yield:

2-(tetrahydropyran-2-yloxy)phenyl bromide (57999-46-9) + 1-[4-[2-(N,N-dimethylamino)ethoxy]phenyl]-2-phenyl-1-butanone (68047-07-4) → 1-[4-(2-Dimethylamino-ethoxy)-phenyl]-2-phenyl-1-[2-(tetrahydro-pyran-2-yloxy)-phenyl]-butan-1-ol (97150-94-2)

Guidance literature:

With n-butyllithium; Multistep reaction; 1.) hexane, THF, -78 deg C, 30 min, 2.) hexane, THF, RT, 10 h;

DOI:10.1021/jm00148a020

upstream raw materials:

2-(tetrahydropyran-2-yloxy)phenyl bromide

1-[4-[2-(N,N-dimethylamino)ethoxy]phenyl]-2-phenyl-1-butanone

3,4-dihydro-2H-pyran

2-hydroxybromobenzene

Downstream raw materials:

2-Hydroxytamoxifen