Technology Process of 4-[3-chloro-5-methoxy-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-indol-1-yl]-benzylamine
There total 8 articles about 4-[3-chloro-5-methoxy-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-indol-1-yl]-benzylamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
{4-[3-chloro-5-methoxy-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-indol-1-yl]-benzyl}-carbamic acid tert-butyl ester;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 48h;
Cooling with ice;
With
sodium carbonate;
In
dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 3 h / 20 °C
1.2: 20 °C / Cooling with ice
2.1: N-chloro-succinimide / acetonitrile / 3 h / Reflux
3.1: trichlorophosphate / 1,4-dioxane / 3 h / Reflux
4.1: hydroxylamine hydrochloride; triethylamine / ethanol; water / 3 h / Reflux
5.1: dichloromethane / 1 h / 20 °C
6.1: N-ethyl-N,N-diisopropylamine / copper diacetate / N,N-dimethyl-formamide / 144 h / 20 °C / Molecular sieve
7.1: trifluoroacetic acid / dichloromethane / 48 h / 20 °C / Cooling with ice
With
N-chloro-succinimide; oxalyl dichloride; hydroxylamine hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; trichlorophosphate;
copper diacetate;
In
1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: trichlorophosphate / 1,4-dioxane / 3 h / Reflux
2: hydroxylamine hydrochloride; triethylamine / ethanol; water / 3 h / Reflux
3: dichloromethane / 1 h / 20 °C
4: N-ethyl-N,N-diisopropylamine / copper diacetate / N,N-dimethyl-formamide / 144 h / 20 °C / Molecular sieve
5: trifluoroacetic acid / dichloromethane / 48 h / 20 °C / Cooling with ice
With
hydroxylamine hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate;
copper diacetate;
In
1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
![{4-[3-chloro-5-methoxy-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-indol-1-yl]-benzyl}-carbamic acid tert-butyl ester](/Databaselist/images/loading.webp)
