benzhydryl 7β-[2-(3-chlorophenyl)acetamido]-3-(1,2,4-triazol-3-yl)thio-3-cephem-4-carboxylate

Base Information

Chemical Name:benzhydryl 7β-[2-(3-chlorophenyl)acetamido]-3-(1,2,4-triazol-3-yl)thio-3-cephem-4-carboxylate
CAS No.:179035-55-3
Molecular Formula:C₃₀H₂₄ClN₅O₄S₂
Molecular Weight:618.137
Hs Code.:

Synonyms:benzhydryl 7β-[2-(3-chlorophenyl)acetamido]-3-(1,2,4-triazol-3-yl)thio-3-cephem-4-carboxylate

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Chemical Property of benzhydryl 7β-[2-(3-chlorophenyl)acetamido]-3-(1,2,4-triazol-3-yl)thio-3-cephem-4-carboxylate

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Technology Process of benzhydryl 7β-[2-(3-chlorophenyl)acetamido]-3-(1,2,4-triazol-3-yl)thio-3-cephem-4-carboxylate

There total 3 articles about benzhydryl 7β-[2-(3-chlorophenyl)acetamido]-3-(1,2,4-triazol-3-yl)thio-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1878-65-5
3-chlorophenylacetic acid

: 179034-53-8
benzhydryl 7β-amino-3-(1,2,4-triazol-3-yl)thio-3-cephem-4-carboxylate

: 179035-55-3
benzhydryl 7β-[2-(3-chlorophenyl)acetamido]-3-(1,2,4-triazol-3-yl)thio-3-cephem-4-carboxylate

Guidance literature:: 3-chlorophenylacetic acid; With N,N-dimethyl-formamide; trichlorophosphate; In ethyl acetate; at 0 ℃; for 0.5h;

benzhydryl 7β-amino-3-(1,2,4-triazol-3-yl)thio-3-cephem-4-carboxylate; With N-Trimethylsilylacetamide; In tetrahydrofuran; ethyl acetate; at -25 - -10 ℃; for 1h;
DOI:10.1016/S0968-0896(00)00163-2

Reference yield:

: diphenylmethyl 7β-formamido-3-methanesulfonyloxy-3-cephem-4-carboxylate

: 179035-55-3
benzhydryl 7β-[2-(3-chlorophenyl)acetamido]-3-(1,2,4-triazol-3-yl)thio-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 52 percent / N,N-diisopropylethylamine / dimethylformamide / 4 h

2.1: 15 percent / HCl / methanol; H₂O; tetrahydrofuran / 1.5 h / 20 °C

3.1: POCl₃; DMF / ethyl acetate / 0.5 h / 0 °C

3.2: 72 percent / N-trimethylsilylacetamide / ethyl acetate; tetrahydrofuran / 1 h / -25 - -10 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trichlorophosphate; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide; 1.1: Substitution / 2.1: Hydrolysis / 3.1: Substitution / 3.2: Acylation;
DOI:10.1016/S0968-0896(00)00163-2

Reference yield:

: 179034-52-7
benzhydryl 7β-formamido-3-(1,2,4-triazol-3-yl)thio-3-cephem-4-carboxylate

: 179035-55-3
benzhydryl 7β-[2-(3-chlorophenyl)acetamido]-3-(1,2,4-triazol-3-yl)thio-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 15 percent / HCl / methanol; H₂O; tetrahydrofuran / 1.5 h / 20 °C

2.1: POCl₃; DMF / ethyl acetate / 0.5 h / 0 °C

2.2: 72 percent / N-trimethylsilylacetamide / ethyl acetate; tetrahydrofuran / 1 h / -25 - -10 °C

With hydrogenchloride; N,N-dimethyl-formamide; trichlorophosphate; In tetrahydrofuran; methanol; water; ethyl acetate; 1.1: Hydrolysis / 2.1: Substitution / 2.2: Acylation;
DOI:10.1016/S0968-0896(00)00163-2