1-[3-(4-acetyl-2-methoxyphenoxy)propyl]-α,α-bis(4-fluorophenyl)-3-piperidinepropanenitrile

Base Information

Chemical Name:1-[3-(4-acetyl-2-methoxyphenoxy)propyl]-α,α-bis(4-fluorophenyl)-3-piperidinepropanenitrile
CAS No.:131911-61-0
Molecular Formula:C₃₂H₃₄F₂N₂O₃
Molecular Weight:532.63
Hs Code.:

Synonyms:1-[3-(4-acetyl-2-methoxyphenoxy)propyl]-α,α-bis(4-fluorophenyl)-3-piperidinepropanenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[3-(4-acetyl-2-methoxyphenoxy)propyl]-α,α-bis(4-fluorophenyl)-3-piperidinepropanenitrile

Chemical Property:

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Technology Process of 1-[3-(4-acetyl-2-methoxyphenoxy)propyl]-α,α-bis(4-fluorophenyl)-3-piperidinepropanenitrile

There total 4 articles about 1-[3-(4-acetyl-2-methoxyphenoxy)propyl]-α,α-bis(4-fluorophenyl)-3-piperidinepropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 58113-30-7
4-(3-chloropropoxy)-3-methoxyacetophenone

: 131912-12-4
α,α-bis(4-fluorophenyl)-3-piperidinepropanenitrile

: 131911-61-0
1-[3-(4-acetyl-2-methoxyphenoxy)propyl]-α,α-bis(4-fluorophenyl)-3-piperidinepropanenitrile

Guidance literature:: With potassium carbonate; potassium iodide; In butan-1-ol; Heating;
DOI:10.1021/jm00114a009

Reference yield:

: 4606-65-9
3-(hydroxymethy)piperidine

: 131911-61-0
1-[3-(4-acetyl-2-methoxyphenoxy)propyl]-α,α-bis(4-fluorophenyl)-3-piperidinepropanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 17.5 h / Ambient temperature

2: 1.) NaH / 1.) DMSO, RT, 1 h, 2.) DMSO, 60 deg C, 15 h

3: 67 percent / phenol, 48percent aq. HBr / 3.5 h / Heating

4: 60 percent / K₂CO₃, KI / butan-1-ol / Heating

With pyridine; hydrogen bromide; sodium hydride; potassium carbonate; potassium iodide; phenol; In butan-1-ol;
DOI:10.1021/jm00114a009

Reference yield:

: 101768-07-4
Toluene-4-sulfonic acid 1-(toluene-4-sulfonyl)-piperidin-3-ylmethyl ester

: 131911-61-0
1-[3-(4-acetyl-2-methoxyphenoxy)propyl]-α,α-bis(4-fluorophenyl)-3-piperidinepropanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMSO, RT, 1 h, 2.) DMSO, 60 deg C, 15 h

2: 67 percent / phenol, 48percent aq. HBr / 3.5 h / Heating

3: 60 percent / K₂CO₃, KI / butan-1-ol / Heating

With hydrogen bromide; sodium hydride; potassium carbonate; potassium iodide; phenol; In butan-1-ol;
DOI:10.1021/jm00114a009