4'-cyano-N-{[(3S)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N,3-dimethyl-4-biphenylcarboxamide

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Chemical Name:4'-cyano-N-{[(3S)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N,3-dimethyl-4-biphenylcarboxamide
CAS No.:1426095-14-8
Molecular Formula:C₂₅H₂₇N₃O₂
Molecular Weight:401.508
Hs Code.:

Synonyms:4'-cyano-N-{[(3S)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N,3-dimethyl-4-biphenylcarboxamide

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Chemical Property of 4'-cyano-N-{[(3S)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N,3-dimethyl-4-biphenylcarboxamide

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Technology Process of 4'-cyano-N-{[(3S)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N,3-dimethyl-4-biphenylcarboxamide

There total 6 articles about 4'-cyano-N-{[(3S)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N,3-dimethyl-4-biphenylcarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426095-82-0
4-bromo-N-{[(3S)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N,2-dimethylbenzamide

: 126747-14-6
4-cyanophenylboronic acid

: 1426095-14-8
4'-cyano-N-{[(3S)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N,3-dimethyl-4-biphenylcarboxamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; water; at 130 ℃; for 0.333333h; Inert atmosphere; Microwave irradiation; Sealed tube;

Reference yield:

: 199175-10-5
1,1-dimethylethyl (3S)-3-(aminomethyl)-1-pyrrolidinecarboxylate

: 1426095-14-8
4'-cyano-N-{[(3S)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N,3-dimethyl-4-biphenylcarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

2.2: 18 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C

5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 0.33 h / 130 °C / Inert atmosphere; Microwave irradiation; Sealed tube

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; mineral oil;

Reference yield:

: 1426095-77-3
1,1-dimethylethyl (3S)-3-({[(4-bromo-2-methylphenyl)carbonyl]amino}methyl)-1-pyrrolidinecarboxylate

: 1426095-14-8
4'-cyano-N-{[(3S)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N,3-dimethyl-4-biphenylcarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

1.2: 18 h / 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 0.33 h / 130 °C / Inert atmosphere; Microwave irradiation; Sealed tube

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; mineral oil;