[4-phenyl-5-(4-chlorophenyl)thiazol-2-yl](1-phenyl-1H-[1,2,3]triazol-4-yl)methylamine

Base Information

Chemical Name:[4-phenyl-5-(4-chlorophenyl)thiazol-2-yl](1-phenyl-1H-[1,2,3]triazol-4-yl)methylamine
CAS No.:1338597-07-1
Molecular Formula:C₂₄H₁₈ClN₅S
Molecular Weight:443.959
Hs Code.:

Synonyms:[4-phenyl-5-(4-chlorophenyl)thiazol-2-yl](1-phenyl-1H-[1,2,3]triazol-4-yl)methylamine

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Chemical Property of [4-phenyl-5-(4-chlorophenyl)thiazol-2-yl](1-phenyl-1H-[1,2,3]triazol-4-yl)methylamine

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Technology Process of [4-phenyl-5-(4-chlorophenyl)thiazol-2-yl](1-phenyl-1H-[1,2,3]triazol-4-yl)methylamine

There total 5 articles about [4-phenyl-5-(4-chlorophenyl)thiazol-2-yl](1-phenyl-1H-[1,2,3]triazol-4-yl)methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1338597-04-8
C₁₈H₁₃ClN₂S

: 622-37-7
Phenyl azide

: 1338597-07-1
[4-phenyl-5-(4-chlorophenyl)thiazol-2-yl](1-phenyl-1H-[1,2,3]triazol-4-yl)methylamine

Guidance literature:: C₁₈H₁₃ClN₂S; With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃; for 0.25h;

Phenyl azide; In water; tert-butyl alcohol; at 20 ℃; for 26h;
DOI:10.1002/jhet.638

Reference yield:

: 43024-03-9
2-bromo-2-(4-chlorophenyl)-1-phenylethanone

: 1338597-07-1
[4-phenyl-5-(4-chlorophenyl)thiazol-2-yl](1-phenyl-1H-[1,2,3]triazol-4-yl)methylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 8 h / Reflux

2.1: potassium carbonate / toluene / 8 h / 110 °C / Inert atmosphere

3.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 0.25 h / 20 °C

3.2: 26 h / 20 °C

With copper(ll) sulfate pentahydrate; potassium carbonate; sodium L-ascorbate; In ethanol; water; toluene; tert-butyl alcohol;
DOI:10.1002/jhet.638

Reference yield:

: 1225875-23-9
C₁₅H₁₁ClN₂S

: 1338597-07-1
[4-phenyl-5-(4-chlorophenyl)thiazol-2-yl](1-phenyl-1H-[1,2,3]triazol-4-yl)methylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / toluene / 8 h / 110 °C / Inert atmosphere

2.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 0.25 h / 20 °C

2.2: 26 h / 20 °C

With copper(ll) sulfate pentahydrate; potassium carbonate; sodium L-ascorbate; In water; toluene; tert-butyl alcohol;
DOI:10.1002/jhet.638