2-(tert-butyl-diphenyl-silanyloxy)-3,3,3-trifluoro-2-{5-[4-(4-fluoro-2-trifluoromethyl-phenyl)-(2R)-2-methyl-piperazine-1-sulfonyl]-thiophen-2-yl}-propionamide

Base Information

Chemical Name:2-(tert-butyl-diphenyl-silanyloxy)-3,3,3-trifluoro-2-{5-[4-(4-fluoro-2-trifluoromethyl-phenyl)-(2R)-2-methyl-piperazine-1-sulfonyl]-thiophen-2-yl}-propionamide
CAS No.:1257229-98-3
Molecular Formula:C₃₅H₃₆F₇N₃O₄S₂Si
Molecular Weight:787.895
Hs Code.:

2-(tert-butyl-diphenyl-silanyloxy)-3,3,3-trifluoro-2-{5-[4-(4-fluoro-2-trifluoromethyl-phenyl)-(2R)-2-methyl-piperazine-1-sulfonyl]-thiophen-2-yl}-propionamide

Synonyms:2-(tert-butyl-diphenyl-silanyloxy)-3,3,3-trifluoro-2-{5-[4-(4-fluoro-2-trifluoromethyl-phenyl)-(2R)-2-methyl-piperazine-1-sulfonyl]-thiophen-2-yl}-propionamide

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Chemical Property of 2-(tert-butyl-diphenyl-silanyloxy)-3,3,3-trifluoro-2-{5-[4-(4-fluoro-2-trifluoromethyl-phenyl)-(2R)-2-methyl-piperazine-1-sulfonyl]-thiophen-2-yl}-propionamide

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Technology Process of 2-(tert-butyl-diphenyl-silanyloxy)-3,3,3-trifluoro-2-{5-[4-(4-fluoro-2-trifluoromethyl-phenyl)-(2R)-2-methyl-piperazine-1-sulfonyl]-thiophen-2-yl}-propionamide

There total 1 articles about 2-(tert-butyl-diphenyl-silanyloxy)-3,3,3-trifluoro-2-{5-[4-(4-fluoro-2-trifluoromethyl-phenyl)-(2R)-2-methyl-piperazine-1-sulfonyl]-thiophen-2-yl}-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1257229-36-9
3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1257229-98-3
2-(tert-butyl-diphenyl-silanyloxy)-3,3,3-trifluoro-2-{5-[4-(4-fluoro-2-trifluoromethyl-phenyl)-(2R)-2-methyl-piperazine-1-sulfonyl]-thiophen-2-yl}-propionamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield: 20.0%

: 18871-66-4
N,N-dimethylacetamide dimethyl acetal

: 1257229-98-3
2-(tert-butyl-diphenyl-silanyloxy)-3,3,3-trifluoro-2-{5-[4-(4-fluoro-2-trifluoromethyl-phenyl)-(2R)-2-methyl-piperazine-1-sulfonyl]-thiophen-2-yl}-propionamide

: 1257229-58-5
2,2,2-trifluoro-1-[5-({(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl}sulfonyl)-2-thienyl]-1-(5-methyl-4H-1,2,4-triazol-3-yl)ethanol

Guidance literature:: N,N-dimethylacetamide dimethyl acetal; 2-(tert-butyl-diphenyl-silanyloxy)-3,3,3-trifluoro-2-{5-[4-(4-fluoro-2-trifluoromethyl-phenyl)-(2R)-2-methyl-piperazine-1-sulfonyl]-thiophen-2-yl}-propionamide; at 20 ℃; for 0.5h;

With acetic acid; hydrazine; at 20 ℃; for 1h;