3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide

Base Information

• Chemical Name: 3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide
• CAS No.: 1257229-36-9
• Molecular Formula: C₁₉H₁₈F₇N₃O₄S₂
• Molecular Weight: 549.49

Synonyms:3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide

Chemical Property of 3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide

Chemical Property:

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Technology Process of 3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide

There total 1 articles about 3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.4%

methyl 3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanoate (1257229-77-8) → 3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide (1257229-36-9) + (2R)-2-[2-bromo-5-({(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl}sulfonyl)-3-thienyl]-3,3,3-trifluoro-2-hydroxypropanamide (1257229-39-2)

Guidance literature:

With ammonia; water; In methanol; at 20 ℃; Product distribution / selectivity;

Reference yield: 27.0%

3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide (1257229-36-9) + tert-butylchlorodiphenylsilane (58479-61-1) → 2-(tert-butyl-diphenyl-silanyloxy)-3,3,3-trifluoro-2-{5-[4-(4-fluoro-2-trifluoromethyl-phenyl)-(2R)-2-methyl-piperazine-1-sulfonyl]-thiophen-2-yl}-propionamide (1257229-98-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide (1257229-36-9) → (S)-3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide (1257229-38-1) + (R)-3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide (1257229-37-0)

Guidance literature:

With Chiralpak ADH column; In methanol; carbon dioxide; Resolution of diastereomeric mixture;

upstream raw materials:

methyl 3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanoate

Downstream raw materials:

N-((dimethylamino)methylene)-3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide

2-(tert-butyl-diphenyl-silanyloxy)-3,3,3-trifluoro-2-{5-[4-(4-fluoro-2-trifluoromethyl-phenyl)-(2R)-2-methyl-piperazine-1-sulfonyl]-thiophen-2-yl}-propionamide

(S)-3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide

(R)-3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide

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