3-(N'-{2-[2-(2-benzyloxycarbonylamino-3-tert-butoxycarbonyl-propionylamino)-4-tert-butoxycarbonyl-butyrylamino]-3-methyl-butyryl}-N-tert-butoxycarbonylmethyl-hydrazinocarbonyl)-acrylic acid benzyl ester

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Chemical Name:3-(N'-{2-[2-(2-benzyloxycarbonylamino-3-tert-butoxycarbonyl-propionylamino)-4-tert-butoxycarbonyl-butyrylamino]-3-methyl-butyryl}-N-tert-butoxycarbonylmethyl-hydrazinocarbonyl)-acrylic acid benzyl ester
CAS No.:685543-81-1
Molecular Formula:C₄₇H₆₅N₅O₁₄
Molecular Weight:924.058
Hs Code.:

3-(<i>N</i>'-{2-[2-(2-benzyloxycarbonylamino-3-<i>tert</i>-butoxycarbonyl-propionylamino)-4-<i>tert</i>-butoxycarbonyl-butyrylamino]-3-methyl-butyryl}-<i>N</i>-<i>tert</i>-butoxycarbonylmethyl-hydrazinocarbonyl)-acrylic acid benzyl ester

Synonyms:3-(N'-{2-[2-(2-benzyloxycarbonylamino-3-tert-butoxycarbonyl-propionylamino)-4-tert-butoxycarbonyl-butyrylamino]-3-methyl-butyryl}-N-tert-butoxycarbonylmethyl-hydrazinocarbonyl)-acrylic acid benzyl ester

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Chemical Property of 3-(N'-{2-[2-(2-benzyloxycarbonylamino-3-tert-butoxycarbonyl-propionylamino)-4-tert-butoxycarbonyl-butyrylamino]-3-methyl-butyryl}-N-tert-butoxycarbonylmethyl-hydrazinocarbonyl)-acrylic acid benzyl ester

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Technology Process of 3-(N'-{2-[2-(2-benzyloxycarbonylamino-3-tert-butoxycarbonyl-propionylamino)-4-tert-butoxycarbonyl-butyrylamino]-3-methyl-butyryl}-N-tert-butoxycarbonylmethyl-hydrazinocarbonyl)-acrylic acid benzyl ester

There total 5 articles about 3-(N'-{2-[2-(2-benzyloxycarbonylamino-3-tert-butoxycarbonyl-propionylamino)-4-tert-butoxycarbonyl-butyrylamino]-3-methyl-butyryl}-N-tert-butoxycarbonylmethyl-hydrazinocarbonyl)-acrylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 13474-68-5,93919-06-3,85602-93-3
Benzyl fumarate

: 646532-79-8
tert-butyl (5S,8S,11S)-5–(2-(tert-butoxy)-2-oxoethyl)-8–(3-(tertbutoxy)-3-oxopropyl)-11-isopropyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13,14-pentaazahexadecan-16-oate

: 685543-81-1
3-(N'-{2-[2-(2-benzyloxycarbonylamino-3-tert-butoxycarbonyl-propionylamino)-4-tert-butoxycarbonyl-butyrylamino]-3-methyl-butyryl}-N-tert-butoxycarbonylmethyl-hydrazinocarbonyl)-acrylic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm049938j

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 685543-81-1
3-(N'-{2-[2-(2-benzyloxycarbonylamino-3-tert-butoxycarbonyl-propionylamino)-4-tert-butoxycarbonyl-butyrylamino]-3-methyl-butyryl}-N-tert-butoxycarbonylmethyl-hydrazinocarbonyl)-acrylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / N-methylmorpholine / dimethylformamide / 16 h / 20 °C

2: 49 percent / HOBt; EDC / dimethylformamide / 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/jm049938j

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 685543-81-1
3-(N'-{2-[2-(2-benzyloxycarbonylamino-3-tert-butoxycarbonyl-propionylamino)-4-tert-butoxycarbonyl-butyrylamino]-3-methyl-butyryl}-N-tert-butoxycarbonylmethyl-hydrazinocarbonyl)-acrylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 51 percent / N-methylmorpholine; EDC / dimethylformamide / 20 °C

2: 49 percent / HOBt; EDC / dimethylformamide / 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/jm049938j