4-methyl-N-{[(1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl]methyl}benzenesulfonamide

Base Information

Chemical Name:4-methyl-N-{[(1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl]methyl}benzenesulfonamide
CAS No.:1310493-47-0
Molecular Formula:C₁₈H₂₈N₂O₂S
Molecular Weight:336.499
Hs Code.:

Synonyms:4-methyl-N-{[(1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl]methyl}benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-methyl-N-{[(1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl]methyl}benzenesulfonamide

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Technology Process of 4-methyl-N-{[(1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl]methyl}benzenesulfonamide

There total 6 articles about 4-methyl-N-{[(1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl]methyl}benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 628-21-7
1,4-Diiodobutane

: 1310493-40-3
N-{[(1S,2S)-2-aminocyclohexyl]methyl}-4-methylbenzenesulfonamide

: 1310493-47-0
4-methyl-N-{[(1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl]methyl}benzenesulfonamide

Guidance literature:: With potassium carbonate; In tetrahydrofuran; for 96h; Reflux;
DOI:10.1021/jo200834n

Reference yield:

: 1310493-51-6
N-[(1S,2R)-2-carbamoylcyclohexyl]benzamide

: 1310493-47-0
4-methyl-N-{[(1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl]methyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 96 h / 0 °C / Reflux; Inert atmosphere

2: triethylamine / chloroform / 15 h / Reflux

3: palladium 10% on activated carbon; hydrogen / ethanol / 36 h / 70 °C / 760.05 Torr / Reflux

4: potassium carbonate / tetrahydrofuran / 96 h / Reflux

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1021/jo200834n

Reference yield:

: 1310493-52-7
(1S,2S)-2-(aminomethyl)-N-benzylcyclohexanamine

: 1310493-47-0
4-methyl-N-{[(1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl]methyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / chloroform / 15 h / Reflux

2: palladium 10% on activated carbon; hydrogen / ethanol / 36 h / 70 °C / 760.05 Torr / Reflux

3: potassium carbonate / tetrahydrofuran / 96 h / Reflux

With palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1021/jo200834n