N,4-dimethyl-N-{[(1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl]methyl}benzenesulfonamide

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Chemical Name:N,4-dimethyl-N-{[(1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl]methyl}benzenesulfonamide
CAS No.:1310493-70-9
Molecular Formula:C₁₉H₃₀N₂O₂S
Molecular Weight:350.525
Hs Code.:

Synonyms:N,4-dimethyl-N-{[(1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl]methyl}benzenesulfonamide

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Chemical Property of N,4-dimethyl-N-{[(1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl]methyl}benzenesulfonamide

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Technology Process of N,4-dimethyl-N-{[(1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl]methyl}benzenesulfonamide

There total 7 articles about N,4-dimethyl-N-{[(1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl]methyl}benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1310493-47-0
4-methyl-N-{[(1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl]methyl}benzenesulfonamide

: 74-88-4
methyl iodide

: 1310493-70-9
N,4-dimethyl-N-{[(1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl]methyl}benzenesulfonamide

Guidance literature:: 4-methyl-N-{[(1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl]methyl}benzenesulfonamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 1h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 15h; Inert atmosphere;
DOI:10.1021/jo200834n

Reference yield:

: 1310493-40-3
N-{[(1S,2S)-2-aminocyclohexyl]methyl}-4-methylbenzenesulfonamide

: 1310493-70-9
N,4-dimethyl-N-{[(1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl]methyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / tetrahydrofuran / 96 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 15 h / 20 °C / Inert atmosphere

With sodium hydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo200834n

Reference yield:

: 1310493-51-6
N-[(1S,2R)-2-carbamoylcyclohexyl]benzamide

: 1310493-70-9
N,4-dimethyl-N-{[(1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl]methyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 96 h / 0 °C / Reflux; Inert atmosphere

2.1: triethylamine / chloroform / 15 h / Reflux

3.1: palladium 10% on activated carbon; hydrogen / ethanol / 36 h / 70 °C / 760.05 Torr / Reflux

4.1: potassium carbonate / tetrahydrofuran / 96 h / Reflux

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere

5.2: 15 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; chloroform; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo200834n