3-Amino-4-(3,4-dichloro-benzyl)-pyrrole-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester

Base Information

Chemical Name:3-Amino-4-(3,4-dichloro-benzyl)-pyrrole-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester
CAS No.:1026966-42-6
Molecular Formula:C₁₆H₁₆Cl₂N₂O₄
Molecular Weight:371.22
Hs Code.:

Synonyms:3-Amino-4-(3,4-dichloro-benzyl)-pyrrole-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester

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Chemical Property of 3-Amino-4-(3,4-dichloro-benzyl)-pyrrole-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester

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Technology Process of 3-Amino-4-(3,4-dichloro-benzyl)-pyrrole-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester

There total 5 articles about 3-Amino-4-(3,4-dichloro-benzyl)-pyrrole-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 81069-32-1
3,4-dichlorocinnamonitrile

: 1026966-42-6
3-Amino-4-(3,4-dichloro-benzyl)-pyrrole-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 5percent Pd/C / ethanol / 9 h / 760 Torr

2: NaH / tetrahydrofuran / 24 h / Ambient temperature

3: AcONa / methanol; H₂O / Ambient temperature

4: 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / CH₂Cl₂ / 24 h / Ambient temperature

With DBN; hydrogen; sodium acetate; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1021/jm00053a008

Reference yield:

: 6287-38-3
3,4-dichlorobenzaldehyde

: 1026966-42-6
3-Amino-4-(3,4-dichloro-benzyl)-pyrrole-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium acetate, pyridine / toluene / 44 h / Heating

2: H₂ / 5percent Pd/C / ethanol / 9 h / 760 Torr

3: NaH / tetrahydrofuran / 24 h / Ambient temperature

4: AcONa / methanol; H₂O / Ambient temperature

5: 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / CH₂Cl₂ / 24 h / Ambient temperature

With pyridine; ammonium acetate; DBN; hydrogen; sodium acetate; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene;
DOI:10.1021/jm00053a008

Reference yield:

: 101724-05-4
3-(3,4-dichlorophenyl)propanenitrile

: 1026966-42-6
3-Amino-4-(3,4-dichloro-benzyl)-pyrrole-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / tetrahydrofuran / 24 h / Ambient temperature

2: AcONa / methanol; H₂O / Ambient temperature

3: 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / CH₂Cl₂ / 24 h / Ambient temperature

With DBN; sodium acetate; sodium hydride; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm00053a008