1-benzyl-N-(4-fluorophenyl)piperidin-4-amine

Base Information

• Chemical Name: 1-benzyl-N-(4-fluorophenyl)piperidin-4-amine
• CAS No.: 131587-27-4
• Molecular Formula: C₁₈H₂₁FN₂
• Molecular Weight: 284.377
• DSSTox Substance ID: DTXSID101037061
• Mol file: 131587-27-4.mol

Synonyms:1-benzyl-N-(4-fluorophenyl)piperidin-4-amine;131587-27-4;N-(1-benzyl-4-piperidinyl)-N-(4-fluorophenyl)amine;para-fluoro 4-ANBP;Oprea1_142950;SCHEMBL3997031;GCHCRHBAGFHFMV-UHFFFAOYSA-N;DTXSID101037061;AKOS000241149;N-Benzyl-4-(4-fluoroanilino)piperidine;Despropionyl N-benzyl p-fluoro norfentanyl;AR-527/43405054;(1-Benzyl-piperidine-4-yl)-(4-fluoro-phenyl)-amine

Chemical Property of 1-benzyl-N-(4-fluorophenyl)piperidin-4-amine

Chemical Property:

• Boiling Point: 404.4±45.0 °C(Predicted)
• PKA: 8.17±0.10(Predicted)
• Density: 1.160±0.06 g/cm3(Predicted)
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 284.16887684
• Heavy Atom Count: 21
• Complexity: 288

Purity/Quality:

99% ^*data from raw suppliers

para-fluoro 4-ANBP ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CN(CCC1NC2=CC=C(C=C2)F)CC3=CC=CC=C3

Technology Process of 1-benzyl-N-(4-fluorophenyl)piperidin-4-amine

There total 3 articles about 1-benzyl-N-(4-fluorophenyl)piperidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-phenylmethyl-4-piperidone (3612-20-2) + 4-fluoroaniline (371-40-4) → 1-benzyl-4-[N-(4-fluorophenyl)amino]piperidine (131587-27-4)

Guidance literature:

1-phenylmethyl-4-piperidone; 4-fluoroaniline; In dichloromethane; at 20 ℃; for 4h;

With sodium triacetoxy borohydride; at 20 ℃; for 60h;

Reference yield: 50.0%

→ 1-benzyl-4-[N-(4-fluorophenyl)amino]piperidine (131587-27-4)

Guidance literature:

Reference yield:

N-benzyl-2-piperidinone (4783-65-7) → 1-benzyl-4-[N-(4-fluorophenyl)amino]piperidine (131587-27-4)

Guidance literature:

With sodium cyanoborohydride; ? molecular sieve; Zinc chloride; 4-fluoroaniline; In methanol; water; toluene;

upstream raw materials:

1-phenylmethyl-4-piperidone

4-fluoroaniline

N-benzyl-2-piperidinone

Downstream raw materials:

N-(1-benzylpiperidin-4-yl)-N-(4-fluorophenyl)propionamide

N-(4-fluorophenyl)-N-(piperidin-4-yl)propionamide

C₁₈H₂₀FN₃O