2-[acetoxy-(2,6-difluoro-phenyl)-methyl]-acrylic acid methyl ester

Base Information

• Chemical Name: 2-[acetoxy-(2,6-difluoro-phenyl)-methyl]-acrylic acid methyl ester
• CAS No.: 868397-94-8
• Molecular Formula: C₁₃H₁₂F₂O₄
• Molecular Weight: 270.233
• Mol file: 868397-94-8.mol

Synonyms:2-[acetoxy-(2,6-difluoro-phenyl)-methyl]-acrylic acid methyl ester

Chemical Property of 2-[acetoxy-(2,6-difluoro-phenyl)-methyl]-acrylic acid methyl ester

Chemical Property:

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Technology Process of 2-[acetoxy-(2,6-difluoro-phenyl)-methyl]-acrylic acid methyl ester

There total 1 articles about 2-[acetoxy-(2,6-difluoro-phenyl)-methyl]-acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C11H10F2O3 + acetyl chloride (75-36-5) → 2-[acetoxy-(2,6-difluoro-phenyl)-methyl]-acrylic acid methyl ester (868397-94-8)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃;

DOI:10.1016/j.jfluchem.2006.10.003

Reference yield:

2-[acetoxy-(2,6-difluoro-phenyl)-methyl]-acrylic acid methyl ester (868397-94-8) + N-(diphenylmethylene)glycine tert-butyl ester (81477-94-3) → (R)-1-(1,1-dimethylethyl)-5-methyl-N-(diphenylmethylene)-(4E)-(2,6-difluorophenyl methylene)-(+/-)-glutamate + (S)-1-(1,1-dimethylethyl)-5-methyl-N-(diphenylmethylene)-(4E)-(2,6-difluorophenyl methylene)-(+/-)-glutamate

Guidance literature:

With cesium hydroxide; (2R,4R,5S)-1-(anthracen-9-ylmethyl)-5-ethenyl-2-[(S)-(prop-2-en-1-yloxy)(quinolin-4-yl)methyl]-1-azabicyclo[2.2.2]octan-1-ium bromide; In dichloromethane; at -78 ℃; for 48h; Title compound not separated from byproducts;

DOI:10.1021/ja052638m

upstream raw materials:

acetyl chloride