(R)-1-(1-(2,4-dichlorophenyl)ethyl)-6-(piperazin-1-yl)-1H-benzo[d]imidazole

Base Information

Chemical Name:(R)-1-(1-(2,4-dichlorophenyl)ethyl)-6-(piperazin-1-yl)-1H-benzo[d]imidazole
CAS No.:1442445-72-8
Molecular Formula:C₁₉H₂₀Cl₂N₄
Molecular Weight:375.301
Hs Code.:

Synonyms:(R)-1-(1-(2,4-dichlorophenyl)ethyl)-6-(piperazin-1-yl)-1H-benzo[d]imidazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-(1-(2,4-dichlorophenyl)ethyl)-6-(piperazin-1-yl)-1H-benzo[d]imidazole

Chemical Property:

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Technology Process of (R)-1-(1-(2,4-dichlorophenyl)ethyl)-6-(piperazin-1-yl)-1H-benzo[d]imidazole

There total 5 articles about (R)-1-(1-(2,4-dichlorophenyl)ethyl)-6-(piperazin-1-yl)-1H-benzo[d]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89981-75-9
1-(2',4'-dichlorophenyl)ethylamine

: 1442445-72-8
(R)-1-(1-(2,4-dichlorophenyl)ethyl)-6-(piperazin-1-yl)-1H-benzo[d]imidazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: (S)-Mandelic acid / isopropyl alcohol; ethanol / 26 h / 30 - 60 °C / Resolution of racemate

1.2: 1 h / 20 °C / Resolution of racemate

2.1: potassium carbonate / dimethyl sulfoxide / 1 h / 120 °C

3.1: hydrogenchloride; iron / water / 2 h / 90 °C

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 18 h / 100 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (S)-Mandelic acid; iron; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; In ethanol; dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol; toluene;

Reference yield:

: 1442445-32-0
(R)-tert-butyl 4-(1-(1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)piperazine-1-carboxylate

: 1442445-72-8
(R)-1-(1-(2,4-dichlorophenyl)ethyl)-6-(piperazin-1-yl)-1H-benzo[d]imidazole

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1442445-21-7
(R)-5-bromo-N-(1-(2,4-dichlorophenyl)ethyl)-2-nitroaniline

: 1442445-72-8
(R)-1-(1-(2,4-dichlorophenyl)ethyl)-6-(piperazin-1-yl)-1H-benzo[d]imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; iron / water / 2 h / 90 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 18 h / 100 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iron; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; In dichloromethane; water; toluene;