benzyl 3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-[4-(pyridin-2-yloxy)phenyl]-5-triisopropylsilanyloxypiperidine-1-carboxylate

Base Information

Chemical Name:benzyl 3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-[4-(pyridin-2-yloxy)phenyl]-5-triisopropylsilanyloxypiperidine-1-carboxylate
CAS No.:911210-58-7
Molecular Formula:C₄₆H₆₁N₃O₇Si
Molecular Weight:796.092
Hs Code.:

benzyl 3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-[4-(pyridin-2-yloxy)phenyl]-5-triisopropylsilanyloxypiperidine-1-carboxylate

Synonyms:benzyl 3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-[4-(pyridin-2-yloxy)phenyl]-5-triisopropylsilanyloxypiperidine-1-carboxylate

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Chemical Property of benzyl 3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-[4-(pyridin-2-yloxy)phenyl]-5-triisopropylsilanyloxypiperidine-1-carboxylate

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Technology Process of benzyl 3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-[4-(pyridin-2-yloxy)phenyl]-5-triisopropylsilanyloxypiperidine-1-carboxylate

There total 14 articles about benzyl 3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-[4-(pyridin-2-yloxy)phenyl]-5-triisopropylsilanyloxypiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-04-6
2-bromo-pyridine

: 911210-34-9
(3R,4R,5S)-4-(4-hydroxy-phenyl)-3-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-triisopropylsilanyloxy-piperidine-1-carboxylic acid benzyl ester

: 911210-58-7
benzyl 3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-[4-(pyridin-2-yloxy)phenyl]-5-triisopropylsilanyloxypiperidine-1-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 120 - 180 ℃; for 1 - 12h;

Reference yield:

: 857272-02-7
6-chloromethyl-4-(3-methoxy-propyl)-4H-benzo[1,4]oxazin-3-one

: 911210-58-7
benzyl 3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-[4-(pyridin-2-yloxy)phenyl]-5-triisopropylsilanyloxypiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 19 h / -10 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol / 0.08 h / 20 °C

2.2: 4 h / 20 °C

3.1: borane-THF / tetrahydrofuran / 1 h / 70 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 1 - 12 h / 120 - 180 °C

With borane-THF; sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 857272-03-8
6-hydroxymethyl-4-(3-methoxy-propyl)-4H-benzo[1,4]oxazin-3-one

: 911210-58-7
benzyl 3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-[4-(pyridin-2-yloxy)phenyl]-5-triisopropylsilanyloxypiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine; thionyl chloride / dichloromethane / 2 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 19 h / -10 - 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol / 0.08 h / 20 °C

3.2: 4 h / 20 °C

4.1: borane-THF / tetrahydrofuran / 1 h / 70 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 1 - 12 h / 120 - 180 °C

With pyridine; thionyl chloride; borane-THF; sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;